Vascular endothelial growth factors C and D and lymphangiogenesis in gastrointestinal tract malignancy.
Authors
Duff, Sarah ELi, Chenggang
Jeziorska, M
Kumar, Shant
Saunders, Mark P
Sherlock, D
O'Dwyer, Sarah T
Jayson, Gordon C
Affiliation
Department of Surgery, Christie Hospital NHS Trust, Wilmslow Road, Manchester M20 4BX, UK. sarah.duff@christie-tr.nwest.nhs.ukIssue Date
2003-08-04
Metadata
Show full item recordAbstract
Vascular endothelial growth factor-C (VEGF-C) and VEGF-D are members of the VEGF family of cytokines and have angiogenic and lymphangiogenic actions. In gastric adenocarcinoma, VEGF-C mRNA and tissue protein expression correlate with lymphatic invasion, lymph node metastasis and in some reports, venous invasion and reduced 5-year survival. Patients with gastric adenocarcinomas containing high levels of VEGF-C expression have significantly reduced 5-year survival rates, and VEGF-C expression is an independent prognostic risk factor for death. The role of VEGF-C in oesophageal squamous and colorectal cancer and VEGF-D in colorectal cancer is not clear, with conflicting reports in the published literature. In order to exploit potential therapeutic applications, further research is necessary to define the precise roles of these cytokines in health and disease.Citation
Vascular endothelial growth factors C and D and lymphangiogenesis in gastrointestinal tract malignancy. 2003, 89 (3):426-30 Br. J. CancerJournal
British Journal of CancerDOI
10.1038/sj.bjc.6601145PubMed ID
12888807Type
ArticleLanguage
enISSN
0007-0920ae974a485f413a2113503eed53cd6c53
10.1038/sj.bjc.6601145