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    Vascular endothelial growth factors C and D and lymphangiogenesis in gastrointestinal tract malignancy.

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    Authors
    Duff, Sarah E
    Li, Chenggang
    Jeziorska, M
    Kumar, Shant
    Saunders, Mark P
    Sherlock, D
    O'Dwyer, Sarah T
    Jayson, Gordon C
    Affiliation
    Department of Surgery, Christie Hospital NHS Trust, Wilmslow Road, Manchester M20 4BX, UK. sarah.duff@christie-tr.nwest.nhs.uk
    Issue Date
    2003-08-04
    
    Metadata
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    Abstract
    Vascular endothelial growth factor-C (VEGF-C) and VEGF-D are members of the VEGF family of cytokines and have angiogenic and lymphangiogenic actions. In gastric adenocarcinoma, VEGF-C mRNA and tissue protein expression correlate with lymphatic invasion, lymph node metastasis and in some reports, venous invasion and reduced 5-year survival. Patients with gastric adenocarcinomas containing high levels of VEGF-C expression have significantly reduced 5-year survival rates, and VEGF-C expression is an independent prognostic risk factor for death. The role of VEGF-C in oesophageal squamous and colorectal cancer and VEGF-D in colorectal cancer is not clear, with conflicting reports in the published literature. In order to exploit potential therapeutic applications, further research is necessary to define the precise roles of these cytokines in health and disease.
    Citation
    Vascular endothelial growth factors C and D and lymphangiogenesis in gastrointestinal tract malignancy. 2003, 89 (3):426-30 Br. J. Cancer
    Journal
    British Journal of Cancer
    URI
    http://hdl.handle.net/10541/78804
    DOI
    10.1038/sj.bjc.6601145
    PubMed ID
    12888807
    Type
    Article
    Language
    en
    ISSN
    0007-0920
    ae974a485f413a2113503eed53cd6c53
    10.1038/sj.bjc.6601145
    Scopus Count
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    All Christie Publications

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