Are BRCA1- and BRCA2-related breast cancers associated with increased mortality?
Affiliation
Academic Unit of Medical Genetics and Regional Genetics Service, St Mary's Hospital, Manchester, UK. Gareth.Evans@CMMC.nhs.ukIssue Date
2004
Metadata
Show full item recordAbstract
There has been contradictory evidence as to whether BRCA1 associated breast cancers have a poorer prognosis than non-BRCA1 cancers. In this issue of Breast Cancer Research Robson and colleagues provide further evidence for poorer survival in BRCA1 carriers and show that it could be attributed to failure to treat small node-negative grade 3 breast cancers with chemotherapy. There still remains little evidence for a survival difference for BRCA2 related breast cancers. Although the high contralateral breast cancer risk is confirmed by this study there is no real evidence for an increase in ipsilateral recurrence or new primary breast cancers in mutation carriers up to the 10-year point.Citation
Are BRCA1- and BRCA2-related breast cancers associated with increased mortality? 2004, 6 (1):E7 Breast Cancer Res.Journal
Breast Cancer ResearchDOI
10.1186/bcr748PubMed ID
14680492Type
ArticleLanguage
enISSN
1465-542Xae974a485f413a2113503eed53cd6c53
10.1186/bcr748