Are BRCA1- and BRCA2-related breast cancers associated with increased mortality?
AffiliationAcademic Unit of Medical Genetics and Regional Genetics Service, St Mary's Hospital, Manchester, UK. Gareth.Evans@CMMC.nhs.uk
MetadataShow full item record
AbstractThere has been contradictory evidence as to whether BRCA1 associated breast cancers have a poorer prognosis than non-BRCA1 cancers. In this issue of Breast Cancer Research Robson and colleagues provide further evidence for poorer survival in BRCA1 carriers and show that it could be attributed to failure to treat small node-negative grade 3 breast cancers with chemotherapy. There still remains little evidence for a survival difference for BRCA2 related breast cancers. Although the high contralateral breast cancer risk is confirmed by this study there is no real evidence for an increase in ipsilateral recurrence or new primary breast cancers in mutation carriers up to the 10-year point.
CitationAre BRCA1- and BRCA2-related breast cancers associated with increased mortality? 2004, 6 (1):E7 Breast Cancer Res.
JournalBreast Cancer Research
- A combined analysis of outcome following breast cancer: differences in survival based on BRCA1/BRCA2 mutation status and administration of adjuvant treatment.
- Authors: Robson ME, Chappuis PO, Satagopan J, Wong N, Boyd J, Goffin JR, Hudis C, Roberge D, Norton L, Bégin LR, Offit K, Foulkes WD
- Issue date: 2004
- Placental cadherin and the basal epithelial phenotype of BRCA1-related breast cancer.
- Authors: Arnes JB, Brunet JS, Stefansson I, Bégin LR, Wong N, Chappuis PO, Akslen LA, Foulkes WD
- Issue date: 2005 Jun 1
- The prevalence of germline BRCA1 and BRCA2 mutations in young women with breast cancer undergoing breast-conservation therapy.
- Authors: Golshan M, Miron A, Nixon AJ, Garber JE, Cash EP, Iglehart JD, Harris JR, Wong JS
- Issue date: 2006 Jul
- Familial breast cancer: clinical response to induction chemotherapy or radiotherapy related to BRCA1/2 mutations status.
- Authors: Fourquet A, Stoppa-Lyonnet D, Kirova YM, Sigal-Zafrani B, Asselain B, Institut Curie Breast Cancer Study Group., Institut Curie Breast Ovary Cancer Risk Study Group.
- Issue date: 2009 Apr
- Contralateral recurrence and prognostic factors in familial non-BRCA1/2-associated breast cancer.
- Authors: Tilanus-Linthorst MM, Alves C, Seynaeve C, Menke-Pluymers MB, Eggermont AM, Brekelmans CT
- Issue date: 2006 Aug