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    Breast density and breast cancer risk factors in a high-risk population.

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    Authors
    Warwick, J
    Pinney, E
    Warren, R
    Duffy, Stephen W
    Howell, Anthony
    Wilson, M
    Cuzick, Jack
    Affiliation
    Department of Mathematics, Statistics and Epidemiology, Cancer Research UK, London WC2A 3PX, UK. jane.warwick@cancer.org.uk
    Issue Date
    2003-02
    
    Metadata
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    Abstract
    This study investigates relationships between familial and hormonal risk factors and breast density in women at high risk of developing breast cancer. The subjects are a subset of 102 women from the international breast cancer intervention study (IBIS), for whom a series of repeated measurements of breast density were available. Details of familial and hormonal risk factors for breast cancer were collected at entry and multivariate ordered logistic regression used to identify risk factors for increased breast density. Lower body mass index and nulliparity were associated with high breast density, whereas smoking was associated with lower breast density. It is not yet known whether a reduction in breast density will lead to a corresponding reduction in breast cancer risk, so we propose that changes in breast density be investigated as a potential early indicator of efficacy in chemoprevention trials for breast cancer.
    Citation
    Breast density and breast cancer risk factors in a high-risk population. 2003, 12 (1):10-6 Breast
    Journal
    Breast
    URI
    http://hdl.handle.net/10541/78795
    DOI
    10.1016/S0960-9776(02)00212-6
    PubMed ID
    14659350
    Type
    Article
    Language
    en
    ISSN
    0960-9776
    ae974a485f413a2113503eed53cd6c53
    10.1016/S0960-9776(02)00212-6
    Scopus Count
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