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dc.contributor.authorSchofield, Paul N
dc.contributor.authorBard, Jonathan B L
dc.contributor.authorBooth, Catherine
dc.contributor.authorBoniver, Jacques
dc.contributor.authorCovelli, Vincenzo
dc.contributor.authorDelvenne, Philippe
dc.contributor.authorEllender, Michele
dc.contributor.authorEngstrom, Wilhelm
dc.contributor.authorGoessner, Wolfgang
dc.contributor.authorGruenberger, Michael
dc.contributor.authorHoefler, Heinz
dc.contributor.authorHopewell, John
dc.contributor.authorMancuso, Mariatheresa
dc.contributor.authorMothersill, Carmel
dc.contributor.authorPotten, Christopher S
dc.contributor.authorQuintanilla-Fend, Leticia
dc.contributor.authorRozell, Bjorn
dc.contributor.authorSariola, Hannu
dc.contributor.authorSundberg, John P
dc.contributor.authorWard, Andrew D
dc.date.accessioned2009-08-25T11:33:29Z
dc.date.available2009-08-25T11:33:29Z
dc.date.issued2004-01-01
dc.identifier.citationPathbase: a database of mutant mouse pathology. 2004, 32 (Database issue):D512-5 Nucleic Acids Res.en
dc.identifier.issn1362-4962
dc.identifier.pmid14681470
dc.identifier.doi10.1093/nar/gkh124
dc.identifier.urihttp://hdl.handle.net/10541/78477
dc.description.abstractPathbase is a database that stores images of the abnormal histology associated with spontaneous and induced mutations of both embryonic and adult mice including those produced by transgenesis, targeted mutagenesis and chemical mutagenesis. Images of normal mouse histology and strain-dependent background lesions are also available. The database and the images are publicly accessible (http://www.pathbase.net) and linked by anatomical site, gene and other identifiers to relevant databases; there are also facilities for public comment and record annotation. The database is structured around a novel ontology of mouse disorders (MPATH) and provides high-resolution downloadable images of normal and diseased tissues that are searchable through orthogonal ontologies for pathology, developmental stage, anatomy and gene attributes (GO terms), together with controlled vocabularies for type of genetic manipulation or mutation, genotype and free text annotation for mouse strain and additional attributes. The database is actively curated and data records assessed by pathologists in the Pathbase Consortium before publication. The database interface is designed to have optimal browser and platform compatibility and to interact directly with other web-based mouse genetic resources.
dc.language.isoenen
dc.subject.meshAnimals
dc.subject.meshComputational Biology
dc.subject.meshDatabases, Factual
dc.subject.meshDisease
dc.subject.meshGenotype
dc.subject.meshInformation Storage and Retrieval
dc.subject.meshInternet
dc.subject.meshMice
dc.subject.meshMutation
dc.subject.meshPathology
dc.subject.meshPhenotype
dc.subject.meshVocabulary, Controlled
dc.titlePathbase: a database of mutant mouse pathology.en
dc.typeArticleen
dc.contributor.departmentDepartment of Anatomy, University of Cambridge, Downing Street, Cambridge CB2 3DY, UK. ps@mole.bio.cam.ac.uken
dc.identifier.journalNucleic Acids Researchen
html.description.abstractPathbase is a database that stores images of the abnormal histology associated with spontaneous and induced mutations of both embryonic and adult mice including those produced by transgenesis, targeted mutagenesis and chemical mutagenesis. Images of normal mouse histology and strain-dependent background lesions are also available. The database and the images are publicly accessible (http://www.pathbase.net) and linked by anatomical site, gene and other identifiers to relevant databases; there are also facilities for public comment and record annotation. The database is structured around a novel ontology of mouse disorders (MPATH) and provides high-resolution downloadable images of normal and diseased tissues that are searchable through orthogonal ontologies for pathology, developmental stage, anatomy and gene attributes (GO terms), together with controlled vocabularies for type of genetic manipulation or mutation, genotype and free text annotation for mouse strain and additional attributes. The database is actively curated and data records assessed by pathologists in the Pathbase Consortium before publication. The database interface is designed to have optimal browser and platform compatibility and to interact directly with other web-based mouse genetic resources.


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