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    Pathbase: a database of mutant mouse pathology.

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    Authors
    Schofield, Paul N
    Bard, Jonathan B L
    Booth, Catherine
    Boniver, Jacques
    Covelli, Vincenzo
    Delvenne, Philippe
    Ellender, Michele
    Engstrom, Wilhelm
    Goessner, Wolfgang
    Gruenberger, Michael
    Hoefler, Heinz
    Hopewell, John
    Mancuso, Mariatheresa
    Mothersill, Carmel
    Potten, Christopher S
    Quintanilla-Fend, Leticia
    Rozell, Bjorn
    Sariola, Hannu
    Sundberg, John P
    Ward, Andrew D
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    Affiliation
    Department of Anatomy, University of Cambridge, Downing Street, Cambridge CB2 3DY, UK. ps@mole.bio.cam.ac.uk
    Issue Date
    2004-01-01
    
    Metadata
    Show full item record
    Abstract
    Pathbase is a database that stores images of the abnormal histology associated with spontaneous and induced mutations of both embryonic and adult mice including those produced by transgenesis, targeted mutagenesis and chemical mutagenesis. Images of normal mouse histology and strain-dependent background lesions are also available. The database and the images are publicly accessible (http://www.pathbase.net) and linked by anatomical site, gene and other identifiers to relevant databases; there are also facilities for public comment and record annotation. The database is structured around a novel ontology of mouse disorders (MPATH) and provides high-resolution downloadable images of normal and diseased tissues that are searchable through orthogonal ontologies for pathology, developmental stage, anatomy and gene attributes (GO terms), together with controlled vocabularies for type of genetic manipulation or mutation, genotype and free text annotation for mouse strain and additional attributes. The database is actively curated and data records assessed by pathologists in the Pathbase Consortium before publication. The database interface is designed to have optimal browser and platform compatibility and to interact directly with other web-based mouse genetic resources.
    Citation
    Pathbase: a database of mutant mouse pathology. 2004, 32 (Database issue):D512-5 Nucleic Acids Res.
    Journal
    Nucleic Acids Research
    URI
    http://hdl.handle.net/10541/78477
    DOI
    10.1093/nar/gkh124
    PubMed ID
    14681470
    Type
    Article
    Language
    en
    ISSN
    1362-4962
    ae974a485f413a2113503eed53cd6c53
    10.1093/nar/gkh124
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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