Role of mitochondrial membrane permeabilization in apoptosis and cancer.
AffiliationCellular and Molecular Pharmacology Group, The Paterson Institute for Cancer Research, Wilmslow Road M20 4BX, Manchester, UK.
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AbstractThe release of proteins from the intermembrane space of mitochondria is one of the pivotal events in the apoptotic process, which can lead to the activation of caspases and the ultimate demise of the cell. How these proteins exit the mitochondria is still a matter of intense debate. Here, we discuss the possible mechanisms behind the release of apoptogenic proteins, the ways in which cancer cells subvert these mechanisms, and the therapeutic regimens that aim to promote the timely loss of integrity of the outer mitochondrial membrane.
CitationRole of mitochondrial membrane permeabilization in apoptosis and cancer. 2004, 23 (16):2850-60 Oncogene
- Regulation and interplay of apoptotic and non-apoptotic cell death.
- Authors: Kim R, Emi M, Tanabe K, Murakami S, Uchida Y, Arihiro K
- Issue date: 2006 Feb
- Mechanisms of cytochrome c release from mitochondria.
- Authors: Garrido C, Galluzzi L, Brunet M, Puig PE, Didelot C, Kroemer G
- Issue date: 2006 Sep
- Regulation of mitochondrial membrane permeabilization by BCL-2 family proteins and caspases.
- Authors: Breckenridge DG, Xue D
- Issue date: 2004 Dec
- [Programmed cell death and apoptosis. The role of mitochondria].
- Authors: Dubin M, Stoppani AO
- Issue date: 2000
- A tale of two mitochondrial channels, MAC and PTP, in apoptosis.
- Authors: Kinnally KW, Antonsson B
- Issue date: 2007 May