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    Role of mitochondrial membrane permeabilization in apoptosis and cancer.

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    Authors
    Henry-Mowatt, Judith
    Dive, Caroline
    Martinou, Jean-Claude
    James, Dominic I
    Affiliation
    Cellular and Molecular Pharmacology Group, The Paterson Institute for Cancer Research, Wilmslow Road M20 4BX, Manchester, UK.
    Issue Date
    2004-04-12
    
    Metadata
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    Abstract
    The release of proteins from the intermembrane space of mitochondria is one of the pivotal events in the apoptotic process, which can lead to the activation of caspases and the ultimate demise of the cell. How these proteins exit the mitochondria is still a matter of intense debate. Here, we discuss the possible mechanisms behind the release of apoptogenic proteins, the ways in which cancer cells subvert these mechanisms, and the therapeutic regimens that aim to promote the timely loss of integrity of the outer mitochondrial membrane.
    Citation
    Role of mitochondrial membrane permeabilization in apoptosis and cancer. 2004, 23 (16):2850-60 Oncogene
    Journal
    Oncogene
    URI
    http://hdl.handle.net/10541/78474
    DOI
    10.1038/sj.onc.1207534
    PubMed ID
    15077148
    Type
    Article
    Language
    en
    ISSN
    0950-9232
    ae974a485f413a2113503eed53cd6c53
    10.1038/sj.onc.1207534
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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