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    X-epilectin: a novel epidermal fucolectin regulated by BMP signalling.

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    Authors
    Massé, Karine
    Baldwin, Rebecca J
    Barnett, Mark W
    Jones, Elizabeth A
    Affiliation
    Molecular Physiology, Department of Biological Sciences, Warwick University, Coventry, UK.
    Issue Date
    2004-12
    
    Metadata
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    Abstract
    This paper reports the cloning and characterisation of a new posterior epidermal marker, X-epilectin, in Xenopus laevis. This gene encodes for a fucolectin, which belongs to the lectin superfamily of carbohydrate binding proteins and specifically binds fucose residues. RT-PCR and in situ hybridisation show that the expression of this gene is switched on during gastrulation and up-regulated during neurula stages and found expressed ubiquitously throughout the epidermis. From tailbud stages, the expression is limited to the dorsal posterior region of the embryo, suggesting that X-epilectin expression is regulated along anteroposterior and dorsoventral gradients during development. In the adult, X-epilectin is mainly expressed in intestinal components, kidney, spinal cord and skin. The effects of growth factors on the regulation of X-epilectin were studied. Change of the fate of animal caps into cement gland or dorsal mesoderm induces a down-regulation of X-epilectin expression in explants treated respectively with ammonium chloride and activin A. We also show that X-epilectin expression is down-regulated by Noggin and tBR and that this effect is inhibited by BMP4 over-expression, suggesting X-epilectin expression is mediated by the BMP signalling pathway.
    Citation
    X-epilectin: a novel epidermal fucolectin regulated by BMP signalling. 2004, 48 (10):1119-29 Int. J. Dev. Biol.
    Journal
    The International Journal of Developmental Biology
    URI
    http://hdl.handle.net/10541/78473
    DOI
    10.1387/ijdb.041892km
    PubMed ID
    15602698
    Type
    Article
    Language
    en
    ISSN
    0214-6282
    ae974a485f413a2113503eed53cd6c53
    10.1387/ijdb.041892km
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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