Effect of TA-CIN (HPV 16 L2E6E7) booster immunisation in vulval intraepithelial neoplasia patients previously vaccinated with TA-HPV (vaccinia virus encoding HPV 16/18 E6E7).
Authors
Davidson, Emma JFaulkner, Rebecca L
Sehr, Peter
Pawlita, Michael
Smyth, Lucy J C
Burt, Deborah J
Tomlinson, Anne E
Hickling, Julian K
Kitchener, Henry C
Stern, Peter L
Affiliation
Immunology Group, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester, UK.Issue Date
2004-07-29
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Heterologous prime-boost vaccination schedules employing TA-HPV, a vaccinia virus encoding HPV 16/18 E6 and E7, in combination with TA-CIN, an HPV 16 L2E6E7 fusion protein, may offer advantages over the use of either agent alone for the immunotherapy of human papillomavirus (HPV) type 16-associated vulval intraepithelial neoplasia (VIN). In the present study, 10 women with HPV 16-positive high grade VIN, previously primed with TA-HPV, received three booster immunisations with TA-CIN. All but one demonstrated HPV 16-specific proliferative T-cell and/or serological responses following vaccination. Three patients additionally showed lesion shrinkage or symptom relief, but no direct correlation between clinical and immunological responses was seen.Citation
Effect of TA-CIN (HPV 16 L2E6E7) booster immunisation in vulval intraepithelial neoplasia patients previously vaccinated with TA-HPV (vaccinia virus encoding HPV 16/18 E6E7). 2004, 22 (21-22):2722-9 VaccineJournal
VaccineDOI
10.1016/j.vaccine.2004.01.049PubMed ID
15246603Type
ArticleLanguage
enISSN
0264-410Xae974a485f413a2113503eed53cd6c53
10.1016/j.vaccine.2004.01.049
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