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    Effect of TA-CIN (HPV 16 L2E6E7) booster immunisation in vulval intraepithelial neoplasia patients previously vaccinated with TA-HPV (vaccinia virus encoding HPV 16/18 E6E7).

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    Authors
    Davidson, Emma J
    Faulkner, Rebecca L
    Sehr, Peter
    Pawlita, Michael
    Smyth, Lucy J C
    Burt, Deborah J
    Tomlinson, Anne E
    Hickling, Julian K
    Kitchener, Henry C
    Stern, Peter L
    Affiliation
    Immunology Group, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester, UK.
    Issue Date
    2004-07-29
    
    Metadata
    Show full item record
    Abstract
    Heterologous prime-boost vaccination schedules employing TA-HPV, a vaccinia virus encoding HPV 16/18 E6 and E7, in combination with TA-CIN, an HPV 16 L2E6E7 fusion protein, may offer advantages over the use of either agent alone for the immunotherapy of human papillomavirus (HPV) type 16-associated vulval intraepithelial neoplasia (VIN). In the present study, 10 women with HPV 16-positive high grade VIN, previously primed with TA-HPV, received three booster immunisations with TA-CIN. All but one demonstrated HPV 16-specific proliferative T-cell and/or serological responses following vaccination. Three patients additionally showed lesion shrinkage or symptom relief, but no direct correlation between clinical and immunological responses was seen.
    Citation
    Effect of TA-CIN (HPV 16 L2E6E7) booster immunisation in vulval intraepithelial neoplasia patients previously vaccinated with TA-HPV (vaccinia virus encoding HPV 16/18 E6E7). 2004, 22 (21-22):2722-9 Vaccine
    Journal
    Vaccine
    URI
    http://hdl.handle.net/10541/78448
    DOI
    10.1016/j.vaccine.2004.01.049
    PubMed ID
    15246603
    Type
    Article
    Language
    en
    ISSN
    0264-410X
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.vaccine.2004.01.049
    Scopus Count
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    All Paterson Institute for Cancer Research

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