Protection and selection for gene therapy in the hematopoietic system.
Affiliation
Cancer Research UK Gene Therapy Group, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Wilmslow Road, Manchester M20 4BX, UK.Issue Date
2004-02
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Hematopoietic stem cell gene therapy is potentially curative for a number of inherited and acquired disorders. However, poor gene transfer and expression in repopulating hematopoietic stem cells attenuate this potential. Here we review potential means of conferring a selective advantage to hematopoietic stem cells and their progeny, and discuss the issues that surround the use of selective advantages in vivo.Citation
Protection and selection for gene therapy in the hematopoietic system. 2004, 6 (2):133-46 J Gene MedJournal
The Journal of Gene MedicineDOI
10.1002/jgm.533PubMed ID
14978767Type
ArticleLanguage
enISSN
1099-498Xae974a485f413a2113503eed53cd6c53
10.1002/jgm.533
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