Protection and selection for gene therapy in the hematopoietic system.
Affiliation
Cancer Research UK Gene Therapy Group, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Wilmslow Road, Manchester M20 4BX, UK.Issue Date
2004-02
Metadata
Show full item recordAbstract
Hematopoietic stem cell gene therapy is potentially curative for a number of inherited and acquired disorders. However, poor gene transfer and expression in repopulating hematopoietic stem cells attenuate this potential. Here we review potential means of conferring a selective advantage to hematopoietic stem cells and their progeny, and discuss the issues that surround the use of selective advantages in vivo.Citation
Protection and selection for gene therapy in the hematopoietic system. 2004, 6 (2):133-46 J Gene MedJournal
The Journal of Gene MedicineDOI
10.1002/jgm.533PubMed ID
14978767Type
ArticleLanguage
enISSN
1099-498Xae974a485f413a2113503eed53cd6c53
10.1002/jgm.533
Scopus Count
Collections
Related articles
- Reduction in hematopoietic stem cell numbers with in vivo drug selection can be partially abrogated by HOXB4 gene expression.
- Authors: Sawai N, Persons DA, Zhou S, Lu T, Sorrentino BP
- Issue date: 2003 Sep
- Sleeping Beauty-Mediated Drug Resistance Gene Transfer in Human Hematopoietic Progenitor Cells.
- Authors: Hyland KA, Olson ER, McIvor RS
- Issue date: 2015 Oct
- Transfer of drug resistance genes into hematopoietic stem cells for marrow protection.
- Authors: Bertino JR
- Issue date: 2008 Oct
- Update on gene therapy for hemoglobin disorders.
- Authors: Persons DA
- Issue date: 2003 Oct
- Vector design for expression of O6-methylguanine-DNA methyltransferase in hematopoietic cells.
- Authors: Schambach A, Baum C
- Issue date: 2007 Aug 1