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    Protection and selection for gene therapy in the hematopoietic system.

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    Authors
    Milsom, Michael D
    Fairbairn, Leslie J
    Affiliation
    Cancer Research UK Gene Therapy Group, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Wilmslow Road, Manchester M20 4BX, UK.
    Issue Date
    2004-02
    
    Metadata
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    Abstract
    Hematopoietic stem cell gene therapy is potentially curative for a number of inherited and acquired disorders. However, poor gene transfer and expression in repopulating hematopoietic stem cells attenuate this potential. Here we review potential means of conferring a selective advantage to hematopoietic stem cells and their progeny, and discuss the issues that surround the use of selective advantages in vivo.
    Citation
    Protection and selection for gene therapy in the hematopoietic system. 2004, 6 (2):133-46 J Gene Med
    Journal
    The Journal of Gene Medicine
    URI
    http://hdl.handle.net/10541/78442
    DOI
    10.1002/jgm.533
    PubMed ID
    14978767
    Type
    Article
    Language
    en
    ISSN
    1099-498X
    ae974a485f413a2113503eed53cd6c53
    10.1002/jgm.533
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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