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    Translocation t(11;14) in multiple myeloma: Analysis of translocation breakpoints on der(11) and der(14) chromosomes suggests complex molecular mechanisms of recombination.

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    Authors
    Fenton, James A L
    Pratt, Guy
    Rothwell, Dominic G
    Rawstron, Andy C
    Morgan, Gareth J
    Affiliation
    Academic Unit of Oncology and Haematology, University of Leeds, Leeds, United Kingdom. jamesf@lrf.leeds.ac.uk
    Issue Date
    2004-02
    
    Metadata
    Show full item record
    Abstract
    We describe the characterization of the genomic DNA breakpoints of two multiple myeloma (MM) patients with t(11;14). IGH translocation events are present in many MM tumors, and it is proposed that they occur early in the pathogenesis, based on the assumption that the translocations are simple reciprocal events mediated by errors in class-switch recombination (CSR). We provide evidence from two patients that the translocation event can be more complex, with DNA from chromosome band 11q13 joined to apparently already recombined hybrid (Smu/Sgamma) switch region sequences. In one case, there was also evidence that a further rearrangement had occurred at the t(11;14) recombination site, resulting in an inversion of 40 bp of the 5'Smu flanking sequence. This suggests that primary IGH arrangements in MM may be more complex than previous myeloma models have suggested, but that they essentially occur through illegitimate CSR events.
    Citation
    Translocation t(11;14) in multiple myeloma: Analysis of translocation breakpoints on der(11) and der(14) chromosomes suggests complex molecular mechanisms of recombination. 2004, 39 (2):151-5 Genes Chromosomes Cancer
    Journal
    Genes, Chromosomes & Cancer
    URI
    http://hdl.handle.net/10541/78434
    DOI
    10.1002/gcc.10304
    PubMed ID
    14695995
    Type
    Article
    Language
    en
    ISSN
    1045-2257
    ae974a485f413a2113503eed53cd6c53
    10.1002/gcc.10304
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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