CLIP-170 family members: a motor-driven ride to microtubule plus ends.
AffiliationThe Paterson Institute for Cancer Research, Wilmslow Road, Manchester M20 4BX, United Kingdom.
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AbstractCLIP-170 family proteins regulate microtubule plus end dynamics. Two reports published in this issue of Developmental Cell show that Bik1 and tip1p, the CLIP-170-like proteins of budding and fission yeast, are carried to microtubule plus ends by kinesin motor proteins. These findings indicate a complex interplay between microtubule-associated proteins and suggest a novel mechanism by which kinesin proteins stabilize microtubules.
CitationCLIP-170 family members: a motor-driven ride to microtubule plus ends. 2004, 6 (6):746-8 Dev. Cell
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