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    Cellular homeostasis and the breast.

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    Authors
    Anderson, Elizabeth
    Affiliation
    Tumour Biochemistry Laboratory, Clinical Research Department, Christie Hospital NHS Trust, Wilmslow Road, Manchester M20 4BX, UK. eanderson@picr.man.ac.uk
    Issue Date
    2004-08-30
    
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    Abstract
    Increasing our knowledge regarding the control of cellular homeostasis in the normal human breast is important in understanding how breast tumours arise and whether compounds used for hormone replacement therapy are able to promote tumour formation In our studies on tissue from pre-menopausal, non-pregnant, non-lactating women, oestradiol is the main ovarian steroid mitogen for the breast epithelium whereas progesterone has little or no effect. Oestradiol appears to influence proliferative activity indirectly via oestrogen-receptor positive cells which control the activity of adjacent division competent cells by means of paracrine or juxtacrine growth factors. After the menopause, however, a mitogenic effect of progesterone becomes apparent which may be due to the reduction in endogenous oestradiol levels or, possibly, to tissue specific alterations in steroid sensitivity. Whatever the mechanism, the proliferative effects of progesterone on the post-menopausal breast have implications for the use of HRT.
    Citation
    Cellular homeostasis and the breast. 2004, 48 Suppl 1:S13-7 Maturitas
    Journal
    Maturitas
    URI
    http://hdl.handle.net/10541/78382
    DOI
    10.1016/j.maturitas.2004.02.010
    PubMed ID
    15337243
    Type
    Article
    Language
    en
    ISSN
    0378-5122
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.maturitas.2004.02.010
    Scopus Count
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    All Paterson Institute for Cancer Research

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