Authors
Anderson, ElizabethAffiliation
Tumour Biochemistry Laboratory, Clinical Research Department, Christie Hospital NHS Trust, Wilmslow Road, Manchester M20 4BX, UK. eanderson@picr.man.ac.ukIssue Date
2004-08-30
Metadata
Show full item recordAbstract
Increasing our knowledge regarding the control of cellular homeostasis in the normal human breast is important in understanding how breast tumours arise and whether compounds used for hormone replacement therapy are able to promote tumour formation In our studies on tissue from pre-menopausal, non-pregnant, non-lactating women, oestradiol is the main ovarian steroid mitogen for the breast epithelium whereas progesterone has little or no effect. Oestradiol appears to influence proliferative activity indirectly via oestrogen-receptor positive cells which control the activity of adjacent division competent cells by means of paracrine or juxtacrine growth factors. After the menopause, however, a mitogenic effect of progesterone becomes apparent which may be due to the reduction in endogenous oestradiol levels or, possibly, to tissue specific alterations in steroid sensitivity. Whatever the mechanism, the proliferative effects of progesterone on the post-menopausal breast have implications for the use of HRT.Citation
Cellular homeostasis and the breast. 2004, 48 Suppl 1:S13-7 MaturitasJournal
MaturitasDOI
10.1016/j.maturitas.2004.02.010PubMed ID
15337243Type
ArticleLanguage
enISSN
0378-5122ae974a485f413a2113503eed53cd6c53
10.1016/j.maturitas.2004.02.010
Scopus Count
Collections
Related articles
- Ovarian steroids and the human breast: regulation of stem cells and cell proliferation.
- Authors: Clarke RB
- Issue date: 2006 Jul 20
- Ovarian steroids and control of proliferation in the normal human breast.
- Authors: Anderson E
- Issue date: 2001 Aug
- Dose-dependent changes of the ratio of apoptosis to proliferation by norethisterone and medroxyprogesterone acetate in human breast epithelial cells.
- Authors: Seeger H, Rakov V, Mueck AO
- Issue date: 2005 Aug
- The effect of progesterone, testosterone and synthetic progestogens on growth factor- and estradiol-treated human cancerous and benign breast cells.
- Authors: Krämer EA, Seeger H, Krämer B, Wallwiener D, Mueck AO
- Issue date: 2006 Nov
- Phytoestrogens and breast cancer: a complex story.
- Authors: Helferich WG, Andrade JE, Hoagland MS
- Issue date: 2008 Oct