Abstract
Sister chromatid segregation in anaphase of mitosis is initiated through cleavage of cohesin by the protease separase. Two studies now show that this view is valid for most chromosomal DNA, but not for the highly repetitive ribosomal DNA (rDNA) and telomeres. The disjunction of these regions of the chromosome occurs in mid-anaphase, long after cohesin cleavage, and is regulated by the conserved phosphatase Cdc14.Citation
Cdc14 phosphatase resolves the rDNA segregation delay. 2004, 6 (6):473-5 Nat. Cell Biol.Journal
Nature Cell BiologyDOI
10.1038/ncb0604-473PubMed ID
15170454Type
ArticleLanguage
enISSN
1465-7392ae974a485f413a2113503eed53cd6c53
10.1038/ncb0604-473
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