Affiliation
Department of Biomolecular Sciences, University of Manchester Institute of Science and Technology, Manchester, United Kingdom.Issue Date
2004-05-15
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Show full item recordAbstract
The recent sequencing of a number of genomes has raised the level of opportunities for studies on proteins. This area of research has been described with the all-embracing term, proteomics. In proteomics, the use of mass spectrometric techniques enables genomic databases to be used to establish the identity of proteins with relatively little data, compared to the era before genome sequencing. The use of related analytical techniques also offers the opportunity to gain information on regulation, via posttranslational modification, and potential new diagnostic and prognostic indicators. Relative quantification of proteins and peptides in cellular and extracellular material remains a challenge for proteomics and mass spectrometry. This review presents an analysis of the present and future impact of these proteomic technologies with emphasis on relative quantification for hematologic research giving an appraisal of their potential benefits.Citation
Proteomics techniques and their application to hematology. 2004, 103 (10):3624-34 BloodJournal
BloodDOI
10.1182/blood-2003-09-3295PubMed ID
14726377Type
ArticleLanguage
enISSN
0006-4971ae974a485f413a2113503eed53cd6c53
10.1182/blood-2003-09-3295
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