AffiliationDepartment of Biomolecular Sciences, University of Manchester Institute of Science and Technology, Manchester, United Kingdom.
MetadataShow full item record
AbstractThe recent sequencing of a number of genomes has raised the level of opportunities for studies on proteins. This area of research has been described with the all-embracing term, proteomics. In proteomics, the use of mass spectrometric techniques enables genomic databases to be used to establish the identity of proteins with relatively little data, compared to the era before genome sequencing. The use of related analytical techniques also offers the opportunity to gain information on regulation, via posttranslational modification, and potential new diagnostic and prognostic indicators. Relative quantification of proteins and peptides in cellular and extracellular material remains a challenge for proteomics and mass spectrometry. This review presents an analysis of the present and future impact of these proteomic technologies with emphasis on relative quantification for hematologic research giving an appraisal of their potential benefits.
CitationProteomics techniques and their application to hematology. 2004, 103 (10):3624-34 Blood
- Challenges in mass spectrometry-based proteomics.
- Authors: Reinders J, Lewandrowski U, Moebius J, Wagner Y, Sickmann A
- Issue date: 2004 Dec
- Relative quantification in proteomics: new approaches for biochemistry.
- Authors: Unwin RD, Evans CA, Whetton AD
- Issue date: 2006 Aug
- Authors: Arthur JM
- Issue date: 2003 Jul
- Proteomics: technologies for protein analysis.
- Authors: Gomase VS, Kale KV, Tagore S, Hatture SR
- Issue date: 2008 Mar
- Recent advances in blood-related proteomics.
- Authors: Thadikkaran L, Siegenthaler MA, Crettaz D, Queloz PA, Schneider P, Tissot JD
- Issue date: 2005 Aug