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dc.contributor.authorFerrarelli, Fabio
dc.contributor.authorHaraldsson, H Magnus
dc.contributor.authorBarnhart, Todd E
dc.contributor.authorRoberts, Andy D
dc.contributor.authorOakes, Terrence R
dc.contributor.authorMassimini, Marcello
dc.contributor.authorStone, Charles K
dc.contributor.authorKalin, Ned H
dc.contributor.authorTononi, Giulio
dc.date.accessioned2009-08-24T14:09:31Z
dc.date.available2009-08-24T14:09:31Z
dc.date.issued2004-08-30
dc.identifier.citationA [17F]-fluoromethane PET/TMS study of effective connectivity. 2004, 64 (2):103-13 Brain Res. Bull.en
dc.identifier.issn0361-9230
dc.identifier.pmid15342097
dc.identifier.doi10.1016/j.brainresbull.2004.04.020
dc.identifier.urihttp://hdl.handle.net/10541/78373
dc.description.abstractWe used transcranial magnetic stimulation (TMS) in combination with positron emission tomography (PET) to investigate the effective connectivity of four cortical regions within the same study. By employing [17F]-[CH3F] ([17F]-fluoromethane) as a radiotracer of blood-flow, we were able to obtain increased sensitivity compared to [15O]-H2O for both cortical and subcortical structures. The brain areas investigated were left primary motor cortex, right primary visual cortex, and left and right prefrontal areas. We found that each site of stimulation yielded a different pattern of activation/deactivation consistent with its anatomical connectivity. Moreover, we found that TMS of prefrontal and motor cortical areas gave rise to trans-synaptic activation of subcortical circuits.
dc.language.isoenen
dc.subject.meshAdult
dc.subject.meshBrain Mapping
dc.subject.meshCerebral Cortex
dc.subject.meshElectric Stimulation
dc.subject.meshHumans
dc.subject.meshHydrocarbons, Fluorinated
dc.subject.meshImage Processing, Computer-Assisted
dc.subject.meshMagnetics
dc.subject.meshMale
dc.subject.meshNeural Networks (Computer)
dc.subject.meshPositron-Emission Tomography
dc.titleA [17F]-fluoromethane PET/TMS study of effective connectivity.en
dc.typeArticleen
dc.contributor.departmentDepartment of Psychiatry, University of Wisconsin, Madison, 6001 Research Park Blvd., Madison, WI 53719, USA.en
dc.identifier.journalBrain Research Bulletinen
html.description.abstractWe used transcranial magnetic stimulation (TMS) in combination with positron emission tomography (PET) to investigate the effective connectivity of four cortical regions within the same study. By employing [17F]-[CH3F] ([17F]-fluoromethane) as a radiotracer of blood-flow, we were able to obtain increased sensitivity compared to [15O]-H2O for both cortical and subcortical structures. The brain areas investigated were left primary motor cortex, right primary visual cortex, and left and right prefrontal areas. We found that each site of stimulation yielded a different pattern of activation/deactivation consistent with its anatomical connectivity. Moreover, we found that TMS of prefrontal and motor cortical areas gave rise to trans-synaptic activation of subcortical circuits.


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