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    A [17F]-fluoromethane PET/TMS study of effective connectivity.

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    Authors
    Ferrarelli, Fabio
    Haraldsson, H Magnus
    Barnhart, Todd E
    Roberts, Andy D
    Oakes, Terrence R
    Massimini, Marcello
    Stone, Charles K
    Kalin, Ned H
    Tononi, Giulio
    Affiliation
    Department of Psychiatry, University of Wisconsin, Madison, 6001 Research Park Blvd., Madison, WI 53719, USA.
    Issue Date
    2004-08-30
    
    Metadata
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    Abstract
    We used transcranial magnetic stimulation (TMS) in combination with positron emission tomography (PET) to investigate the effective connectivity of four cortical regions within the same study. By employing [17F]-[CH3F] ([17F]-fluoromethane) as a radiotracer of blood-flow, we were able to obtain increased sensitivity compared to [15O]-H2O for both cortical and subcortical structures. The brain areas investigated were left primary motor cortex, right primary visual cortex, and left and right prefrontal areas. We found that each site of stimulation yielded a different pattern of activation/deactivation consistent with its anatomical connectivity. Moreover, we found that TMS of prefrontal and motor cortical areas gave rise to trans-synaptic activation of subcortical circuits.
    Citation
    A [17F]-fluoromethane PET/TMS study of effective connectivity. 2004, 64 (2):103-13 Brain Res. Bull.
    Journal
    Brain Research Bulletin
    URI
    http://hdl.handle.net/10541/78373
    DOI
    10.1016/j.brainresbull.2004.04.020
    PubMed ID
    15342097
    Type
    Article
    Language
    en
    ISSN
    0361-9230
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.brainresbull.2004.04.020
    Scopus Count
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    All Paterson Institute for Cancer Research

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