Authors
Ferrarelli, FabioHaraldsson, H Magnus
Barnhart, Todd E
Roberts, Andy D
Oakes, Terrence R
Massimini, Marcello
Stone, Charles K
Kalin, Ned H
Tononi, Giulio
Affiliation
Department of Psychiatry, University of Wisconsin, Madison, 6001 Research Park Blvd., Madison, WI 53719, USA.Issue Date
2004-08-30
Metadata
Show full item recordAbstract
We used transcranial magnetic stimulation (TMS) in combination with positron emission tomography (PET) to investigate the effective connectivity of four cortical regions within the same study. By employing [17F]-[CH3F] ([17F]-fluoromethane) as a radiotracer of blood-flow, we were able to obtain increased sensitivity compared to [15O]-H2O for both cortical and subcortical structures. The brain areas investigated were left primary motor cortex, right primary visual cortex, and left and right prefrontal areas. We found that each site of stimulation yielded a different pattern of activation/deactivation consistent with its anatomical connectivity. Moreover, we found that TMS of prefrontal and motor cortical areas gave rise to trans-synaptic activation of subcortical circuits.Citation
A [17F]-fluoromethane PET/TMS study of effective connectivity. 2004, 64 (2):103-13 Brain Res. Bull.Journal
Brain Research BulletinDOI
10.1016/j.brainresbull.2004.04.020PubMed ID
15342097Type
ArticleLanguage
enISSN
0361-9230ae974a485f413a2113503eed53cd6c53
10.1016/j.brainresbull.2004.04.020
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