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dc.contributor.authorArmstrong, Anne C
dc.contributor.authorDermime, Said
dc.contributor.authorMulryan, Kate
dc.contributor.authorStern, Peter L
dc.contributor.authorBhattacharyya, Tapan
dc.contributor.authorHawkins, Robert E
dc.date.accessioned2009-08-24T16:10:55Z
dc.date.available2009-08-24T16:10:55Z
dc.date.issued2009-08-24T16:10:55Z
dc.identifier.citationAdoptive transfer of anti-idiotypic T cells cure mice of disseminated B cell lymphoma., 27 (3):227-31 J. Immunother.en
dc.identifier.issn1524-9557
dc.identifier.pmid15076140
dc.identifier.urihttp://hdl.handle.net/10541/78365
dc.description.abstractThere is extensive interest in idiotypic vaccination as a treatment of lymphoma. An alternative approach is the adoptive transfer of in vitro generated T cells. This strategy has been used to treat posttransplantation EBV-related diseases. The ability to generate in vitro T cells to peptides derived from immunoglobulin idiotypes raises the possibility of directly using such cells as a treatment of lymphoma. Investigating the adoptive transfer of specific T cells to idiotype derived peptides in a murine lymphoma model is therefore an important part of the clinical translation of this alternative approach. We have generated an idiotype-specific T cell line, able to recognise a defined, naturally processed idiotype-derived epitope. This line has been used to successfully treat mice with disseminated lymphoma supporting the clinical use of idiotype specific T cells.
dc.language.isoenen
dc.subjectCell Line Tumouren
dc.subject.meshAdenoviridae
dc.subject.meshAdoptive Transfer
dc.subject.meshAnimals
dc.subject.meshCell Division
dc.subject.meshCell Line, Tumor
dc.subject.meshChromium
dc.subject.meshEnzyme-Linked Immunosorbent Assay
dc.subject.meshEpitopes
dc.subject.meshFemale
dc.subject.meshImmunoglobulin Fragments
dc.subject.meshImmunoglobulin Idiotypes
dc.subject.meshImmunoglobulins
dc.subject.meshImmunotherapy
dc.subject.meshImmunotherapy, Adoptive
dc.subject.meshInterferon-gamma
dc.subject.meshLymphoma
dc.subject.meshLymphoma, B-Cell
dc.subject.meshMice
dc.subject.meshMice, Inbred BALB C
dc.subject.meshPeptides
dc.subject.meshReverse Transcriptase Polymerase Chain Reaction
dc.subject.meshT-Lymphocytes
dc.subject.meshTime Factors
dc.titleAdoptive transfer of anti-idiotypic T cells cure mice of disseminated B cell lymphoma.en
dc.contributor.departmentCancer Research UK Department of Medical Oncology, Paterson Institute of Cancer Research, Christie Hospital NHS Trust, Manchester, UK.en
dc.identifier.journalJournal of Immunotherapyen
html.description.abstractThere is extensive interest in idiotypic vaccination as a treatment of lymphoma. An alternative approach is the adoptive transfer of in vitro generated T cells. This strategy has been used to treat posttransplantation EBV-related diseases. The ability to generate in vitro T cells to peptides derived from immunoglobulin idiotypes raises the possibility of directly using such cells as a treatment of lymphoma. Investigating the adoptive transfer of specific T cells to idiotype derived peptides in a murine lymphoma model is therefore an important part of the clinical translation of this alternative approach. We have generated an idiotype-specific T cell line, able to recognise a defined, naturally processed idiotype-derived epitope. This line has been used to successfully treat mice with disseminated lymphoma supporting the clinical use of idiotype specific T cells.


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