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    Measurements of hypoxia using pimonidazole and polarographic oxygen-sensitive electrodes in human cervix carcinomas.

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    Authors
    Nordsmark, Marianne
    Loncaster, Juliette A
    Aquino-Parsons, Christina
    Chou, Shu-Chuan
    Ladekarl, Morten
    Havsteen, Hanne
    Lindegaard, Jacob C
    Davidson, Susan E
    Varia, Mahesh
    West, Catharine M L
    Hunter, Robin D
    Overgaard, Jens
    Raleigh, James A
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    Affiliation
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Aarhus, Denmark.
    Issue Date
    2003-04
    
    Metadata
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    Abstract
    BACKGROUND AND PURPOSE: The measurement of tumour oxygenation using Eppendorf oxygen-sensitive needle electrodes can provide prognostic information but the method is limited to accessible tumours that are suitable for electrode insertion. In this paper the aim was to study the relationship between such physiological measurements of tumour hypoxia and the labelling of tumours with the hypoxia-specific marker pimonidazole. MATERIALS AND METHODS: Assessment of tumour oxygen partial pressure (pO(2)) using an Eppendorf pO(2) histograph and immunohistochemical pimonidazole labelling was carried out in 86 patients with primary cervix carcinomas. Pimonidazole was given as a single injection (0.5 g/m(2) i.v.) and 10-24 h later pO(2) measurements were made and biopsies taken. Tumour oxygenation status was evaluated as the median tumour pO(2) and the fraction of pO(2) values
    Citation
    Measurements of hypoxia using pimonidazole and polarographic oxygen-sensitive electrodes in human cervix carcinomas. 2003, 67 (1):35-44 Radiother Oncol
    Journal
    Radiotherapy and Oncology
    URI
    http://hdl.handle.net/10541/78229
    PubMed ID
    12758238
    Type
    Article
    Language
    en
    ISSN
    0167-8140
    Collections
    All Christie Publications

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