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Foci of amorphous/granulofilamentous matrix in the extracellular domain of tumours: a study of 34 cases. 1. Ultrastructural characterisation.

dc.contributor.authorEyden, Brian P
dc.contributor.authorRu, Y
dc.date.accessioned2009-08-21T11:54:48Z
dc.date.available2009-08-21T11:54:48Z
dc.date.issued2003-04
dc.identifier.citationFoci of amorphous/granulofilamentous matrix in the extracellular domain of tumours: a study of 34 cases. 1. Ultrastructural characterisation. 2003, 35 (2):99-109 J. Submicrosc. Cytol. Pathol.en
dc.identifier.issn1122-9497
dc.identifier.pmid12974323
dc.identifier.urihttp://hdl.handle.net/10541/78178
dc.description.abstractThe distribution and the appearance of foci of extracellular amorphous/granulofilamentous material (FEAM) in 34 human tumours are described. FEAM were rounded to oval, or more elongated or irregular elements of discretely delineated dense material lying in the extracellular space of tumours. They varied in size and abundance, sometimes coalescing into more extensive areas of dense material. At high magnification, FEAM exhibited a granular and finely filamentous substructure. Variations in the electron-density of FEAM were noted. Some FEAM were found associated with the surfaces of tumour cells, on occasion with subplasmalemmal linear densities. FEAM was also sometimes associated with matrix filaments, often collagen. Material of similar substructure and density was also associated with some vessels. FEAM were mostly found in tumours showing mesenchymal differentiation. The nature and origin of FEAM is discussed.
dc.language.isoenen
dc.subjectCanceren
dc.subject.meshAdolescent
dc.subject.meshAdult
dc.subject.meshAged
dc.subject.meshAged, 80 and over
dc.subject.meshExtracellular Matrix
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshInclusion Bodies
dc.subject.meshMale
dc.subject.meshMicroscopy, Electron
dc.subject.meshMiddle Aged
dc.subject.meshNeoplasms
dc.titleFoci of amorphous/granulofilamentous matrix in the extracellular domain of tumours: a study of 34 cases. 1. Ultrastructural characterisation.en
dc.typeArticleen
dc.contributor.departmentDepartment of Histopathology, Christie Hospital NHS Trust, Manchester, UK. brian.eyden@christie-tr.nwest.nhs.uken
dc.identifier.journalJournal of Submicroscopic Cytology and Pathologyen
html.description.abstractThe distribution and the appearance of foci of extracellular amorphous/granulofilamentous material (FEAM) in 34 human tumours are described. FEAM were rounded to oval, or more elongated or irregular elements of discretely delineated dense material lying in the extracellular space of tumours. They varied in size and abundance, sometimes coalescing into more extensive areas of dense material. At high magnification, FEAM exhibited a granular and finely filamentous substructure. Variations in the electron-density of FEAM were noted. Some FEAM were found associated with the surfaces of tumour cells, on occasion with subplasmalemmal linear densities. FEAM was also sometimes associated with matrix filaments, often collagen. Material of similar substructure and density was also associated with some vessels. FEAM were mostly found in tumours showing mesenchymal differentiation. The nature and origin of FEAM is discussed.


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