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dc.contributor.authorCoyne, John
dc.contributor.authorBanerjee, Saumitra S
dc.contributor.authorBromley, Michael
dc.contributor.authorMills, S
dc.contributor.authorDiss, T C
dc.contributor.authorHarris, Martin
dc.date.accessioned2009-08-21T10:01:45Z
dc.date.available2009-08-21T10:01:45Z
dc.date.issued2004-04
dc.identifier.citationPost-transplant T-cell lymphoproliferative disorder/T-cell lymphoma: a report of three cases of T-anaplastic large-cell lymphoma with cutaneous presentation and a review of the literature. 2004, 44 (4):387-93 Histopathologyen
dc.identifier.issn0309-0167
dc.identifier.pmid15049906
dc.identifier.doi10.1111/j.1365-2559.2004.01847.x
dc.identifier.urihttp://hdl.handle.net/10541/78129
dc.description.abstractAIMS: To report the clinical, pathological and immunohistochemical features of three cases of post-transplant T-cell lymphoproliferative disorder (T-PTLD) T-cell lymphoma with primary cutaneous presentation. METHODS AND RESULTS: Three cases of primary cutaneous post-transplantation anaplastic large-cell lymphomas occurred in renal transplant recipients and were shown to display a T-cell immunophenotype; all were ALK 1 protein and EMA negative and two were Epstein-Barr virus positive using in-situ hybridization. Two displayed a CD4+ phenotype, two were focally CD56+ and all three were negative for the cytolytic enzyme granzyme B. In two cases monoclonality was established by T-cell receptor gene rearrangement study. All presented with nodular cutaneous involvement and all were ultimately fatal. CONCLUSION: T-PTLDs are uncommon histological subtypes both in a general context and associated with cutaneous presentation. Our findings suggest clinicopathological and immunophenotypic similarities to primary cutaneous anaplastic large-cell lymphoma but with a progressive clinical behaviour similar to previously reported T-PTLD and to systemic nodal ALK- anaplastic large-cell lymphoma.
dc.language.isoenen
dc.subject.meshAdult
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshImmunohistochemistry
dc.subject.meshIn Situ Hybridization
dc.subject.meshKidney Transplantation
dc.subject.meshLupus Erythematosus, Systemic
dc.subject.meshLymphoma, Large B-Cell, Diffuse
dc.subject.meshLymphoma, T-Cell
dc.subject.meshLymphoproliferative Disorders
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshSkin Diseases
dc.titlePost-transplant T-cell lymphoproliferative disorder/T-cell lymphoma: a report of three cases of T-anaplastic large-cell lymphoma with cutaneous presentation and a review of the literature.en
dc.typeArticleen
dc.contributor.departmentDepartment of Histopathology, Withenshawe Hospital, Manchester, UK.en
dc.identifier.journalHistopathologyen
html.description.abstractAIMS: To report the clinical, pathological and immunohistochemical features of three cases of post-transplant T-cell lymphoproliferative disorder (T-PTLD) T-cell lymphoma with primary cutaneous presentation. METHODS AND RESULTS: Three cases of primary cutaneous post-transplantation anaplastic large-cell lymphomas occurred in renal transplant recipients and were shown to display a T-cell immunophenotype; all were ALK 1 protein and EMA negative and two were Epstein-Barr virus positive using in-situ hybridization. Two displayed a CD4+ phenotype, two were focally CD56+ and all three were negative for the cytolytic enzyme granzyme B. In two cases monoclonality was established by T-cell receptor gene rearrangement study. All presented with nodular cutaneous involvement and all were ultimately fatal. CONCLUSION: T-PTLDs are uncommon histological subtypes both in a general context and associated with cutaneous presentation. Our findings suggest clinicopathological and immunophenotypic similarities to primary cutaneous anaplastic large-cell lymphoma but with a progressive clinical behaviour similar to previously reported T-PTLD and to systemic nodal ALK- anaplastic large-cell lymphoma.


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