Development of a simultaneous boost IMRT class solution for a hypofractionated prostate cancer protocol.
AffiliationNorth Western Medical Physics and Clinical Oncology, Christie Hospital NHS Trust, Manchester M20 4BX, UK.
MetadataShow full item record
AbstractThe purpose of this work was to develop a robust technique for planning intensity-modulated radiation therapy (IMRT) for prostate cancer patients who are to be entered into a proposed hypofractionated dose escalation study. In this study the dose escalation will be restricted to the prostate alone, which may be regarded as a concurrent boost volume within the overall planning target volume (PTV). The dose to the prostate itself is to be delivered in 3 Gy fractions, and for this phase of the study the total prostate dose will be 57 Gy in 19 fractions, with 50 Gy prescribed to the rest of the PTV. If acute toxicity results are acceptable, the next phase will escalate doses to 60 Gy in 20 x 3 Gy fractions. There will be 30 patients in each arm. This work describes the class solution which was developed to create IMRT plans for this study, and which enabled the same set of inverse planning parameters to be used during optimization for every patient with minimal planner intervention. The resulting dose distributions were compared with those that would be achieved from a 3D conformal radiotherapy (3DCRT) technique that used a multileaf collimator (MLC) but no intensity modulation to treat the PTV, followed by a sequential boost to raise the prostate to 57 Gy. The two methods were tested on anatomical data sets for a series of 10 patients who would have been eligible for this study, and the techniques were compared in terms of doses to the target volumes and the organs at risk. The IMRT method resulted in much greater sparing of the rectum and bladder than the 3DCRT technique, whilst still delivering acceptable doses to the target volumes. In particular, the volume of rectum receiving the minimum PTV dose of 47.5 Gy was reduced from a mean value of 36.9% (range 23.4% to 61.0%) to 18.6% (10.3% to 29.0%). In conclusion, it was found possible to use a class solution approach to produce IMRT dose escalated plans. This IMRT technique has since been implemented clinically for patients enrolled in the hypofractionated dose escalation study.
CitationDevelopment of a simultaneous boost IMRT class solution for a hypofractionated prostate cancer protocol. 2004, 77 (917):377-86 Br J Radiol
JournalThe British Journal of Radiology
- Dosimetry and radiobiologic model comparison of IMRT and 3D conformal radiotherapy in treatment of carcinoma of the prostate.
- Authors: Luxton G, Hancock SL, Boyer AL
- Issue date: 2004 May 1
- Assessment of different IMRT boost delivery methods on target coverage and normal-tissue sparing.
- Authors: Dogan N, King S, Emami B, Mohideen N, Mirkovic N, Leybovich LB, Sethi A
- Issue date: 2003 Dec 1
- Inverse and forward optimization of one- and two-dimensional intensity-modulated radiation therapy-based treatment of concave-shaped planning target volumes: the case of prostate cancer.
- Authors: Corletto D, Iori M, Paiusco M, Brait L, Broggi S, Ceresoli G, Iotti C, Calandrino R, Fiorino C
- Issue date: 2003 Feb
- Comparison of treatment volumes and techniques in prostate cancer radiation therapy.
- Authors: Lee CT, Dong L, Ahamad AW, Choi H, Cheung R, Lee AK, Horne DF Jr, Breaux AJ, Kuban DA
- Issue date: 2005 Dec
- Intensity-modulated radiation therapy for pancreatic and prostate cancer using pulsed low-dose rate delivery techniques.
- Authors: Li J, Lang J, Wang P, Kang S, Lin MH, Chen X, Chen F, Guo M, Chen L, Ma CM
- Issue date: 2014 Winter