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    An evaluation of gemcitabines differential radiosensitising effect in related bladder cancer cell lines.

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    Authors
    Sangar, Vijay K
    Cowan, Richard A
    Margison, Geoffrey P
    Hendry, Jolyon H
    Clarke, Noel W
    Affiliation
    Cancer Research UK Experimental Radiation Oncology Group, Paterson Institute for Cancer Research, Manchester M20 4BX, UK. vipol@aol.com
    Issue Date
    2004-01-26
    
    Metadata
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    Abstract
    The aim of this study was to establish the radiosensitising properties of gemcitabine in a pair of related bladder tumour cell lines with differential radiosensitivity. The radioresistant bladder tumour cell line MGH-U1 and its radiosensitive mutant clone, S40b (both p53 mutant), had SF(2) values (surviving fraction at 2 Gy) of 0.98 and 0.64, respectively (P<0.001). Colony-forming assays showed that at 0.01 microM gemcitabine radiosensitisation occurred only in the S40b cell line (dose-modifying factor (DMF)=1.4). At 0.3 microM (killing 50% of cells), both cell lines were radiosensitised; DMF=2.25 and 1.2 for MGH-U1 and S40b, respectively. These data suggest that gemcitabine is an effective radiosensitiser in bladder cancer cell lines, with greater sensitisation in the radioresistant parental line-a feature that should be useful in a clinical setting.
    Citation
    An evaluation of gemcitabines differential radiosensitising effect in related bladder cancer cell lines. 2004, 90 (2):542-8 Br. J. Cancer
    Journal
    British Journal of Cancer
    URI
    http://hdl.handle.net/10541/78109
    DOI
    10.1038/sj.bjc.6601538
    PubMed ID
    14735206
    Type
    Article
    Language
    en
    ISSN
    0007-0920
    ae974a485f413a2113503eed53cd6c53
    10.1038/sj.bjc.6601538
    Scopus Count
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    All Christie Publications
    All Paterson Institute for Cancer Research

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