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dc.contributor.authorHarris, Maggie A
dc.contributor.authorWise, M S
dc.contributor.authorBonington, A
dc.contributor.authorSlevin, Nicholas J
dc.date.accessioned2009-08-21T09:27:48Z
dc.date.available2009-08-21T09:27:48Z
dc.date.issued2004-06
dc.identifier.citationRadical radiotherapy for early laryngeal cancer in a patient with human immunodeficiency virus: no evidence of increased toxicity. 2004, 77 (918):519-20 Br J Radiolen
dc.identifier.issn0007-1285
dc.identifier.pmid15151976
dc.identifier.doi10.1259/bjr/51408454
dc.identifier.urihttp://hdl.handle.net/10541/78103
dc.description.abstractThere are very few reported cases of laryngeal squamous cell carcinoma (SCC) in patients with a background of human immunodeficiency virus (HIV) infection. We report a case of a 42-year-old man who developed a T2 N0 left vocal cord well differentiated SCC with an 11 year history of HIV infection. He successfully completed a course of radical radiotherapy 66 Gy in 33 fractions over 47 days. During his treatment he experienced only a grade 1 Radiation Therapy Oncology Group (RTOG) acute toxicity reaction to the larynx and no weight loss. At 32 months follow up he remains disease free and has no significant late morbidity. Prior to his radiotherapy his CD4 count was 350 cells mm(-3); we discuss the view that the treatment chosen needs to be individually tailored with respect to the patient's immune status.
dc.language.isoenen
dc.subjectLaryngeal Canceren
dc.subject.meshAdult
dc.subject.meshCarcinoma, Squamous Cell
dc.subject.meshErythema
dc.subject.meshHIV Infections
dc.subject.meshHumans
dc.subject.meshLaryngeal Neoplasms
dc.subject.meshMale
dc.subject.meshRadiation Injuries
dc.subject.meshSkin
dc.subject.meshVocal Cords
dc.titleRadical radiotherapy for early laryngeal cancer in a patient with human immunodeficiency virus: no evidence of increased toxicity.en
dc.typeArticleen
dc.contributor.departmentDepartment of Clinical Oncology, Christie Hospital NHS Trust, Wilmslow Road, Withington, Manchester M20 4BX, UK.en
dc.identifier.journalThe British Journal of Radiologyen
html.description.abstractThere are very few reported cases of laryngeal squamous cell carcinoma (SCC) in patients with a background of human immunodeficiency virus (HIV) infection. We report a case of a 42-year-old man who developed a T2 N0 left vocal cord well differentiated SCC with an 11 year history of HIV infection. He successfully completed a course of radical radiotherapy 66 Gy in 33 fractions over 47 days. During his treatment he experienced only a grade 1 Radiation Therapy Oncology Group (RTOG) acute toxicity reaction to the larynx and no weight loss. At 32 months follow up he remains disease free and has no significant late morbidity. Prior to his radiotherapy his CD4 count was 350 cells mm(-3); we discuss the view that the treatment chosen needs to be individually tailored with respect to the patient's immune status.


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