AffiliationYoung Oncology Unit, Christie Hospital, Wilmslow Road, Manchester M20 4BX, UK.
MetadataShow full item record
AbstractSymptom interval (SI), the time from first symptom/sign to diagnosis and initiation of treatment, appears to be principally influenced by tumour biology. Whether the age of the patient, patient delay, professional delay and access to health professionals influences the SI in bone tumours was investigated in this study. 115 patients with newly diagnosed osteosarcoma and Ewing's sarcoma were retrospectively reviewed. The median total SI for all bone tumours was 3.8 months (range 1-46 months). Patients older than 12 years had a longer SI (P = 0.05) and more patient delays (P = 0.02). Total SI and professional delays were longer if the General Practitioner was first seen compared with an Accident and Emergency Consultant (P = 0.02 and 0.02, respectively). However, SI did not influence overall and event-free survival in this series. Bone tumour patients have long SIs that are significantly affected by age and local health-care support systems. Early referral to specialists would help to alleviate anxiety and distress to the patient and family, even if currently delay does not influence outcome.
CitationSymptom interval in young people with bone cancer. 2004, 40 (15):2280-6 Eur. J. Cancer
JournalEuropean Journal of Cancer
- Presenting symptoms and treatment delay in osteosarcoma and Ewing's sarcoma.
- Authors: Sneppen O, Hansen LM
- Issue date: 1984
- Comparative analysis between osteosarcoma and Ewing's sarcoma: evaluation of the time from onset of signs and symptoms until diagnosis.
- Authors: Guerra RB, Tostes MD, da Costa Miranda L, Pires de Camargo O, Baptista AM, Caiero MT, Dos Santos Machado TM, Abadi MD, Mendes de Oliveira CR, Filippi RZ
- Issue date: 2006 Apr
- Osteosarcoma and Ewing's sarcoma in children and adolescents: retrospective clinicopathological study.
- Authors: Ilić I, Manojlović S, Cepulić M, Orlić D, Seiwerth S
- Issue date: 2004 Dec
- Treatment delay of bone tumours, compilation of a sociodemographic risk profile: a retrospective study.
- Authors: Schnurr C, Pippan M, Stuetzer H, Delank KS, Michael JW, Eysel P
- Issue date: 2008 Jan 23
- Long-term follow-up of 15 patients with non-metastatic Ewing's sarcoma and a skip lesion.
- Authors: Jiya TU, Wuisman PI
- Issue date: 2005 Dec