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    Positron emission tomography imaging of cell proliferation in oncology.

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    Authors
    Kenny, L M
    Aboagye, E O
    Price, Patricia M
    Affiliation
    Molecular Therapy Group and PET Oncology Group, Hammersmith Hospital, London, UK.
    Issue Date
    2004-05
    
    Metadata
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    Abstract
    Tumour-cell proliferation is a hallmark of the malignant phenotype. Positron emission tomography (PET) offers a unique method of imaging biological and biochemical changes in vivo. Radiolabelled thymidine and thymidine analogues are currently in development as PET tracers. By studying the uptake and kinetics of such compounds using PET, a measure of DNA synthesis and hence cell proliferation can be obtained. Molecular imaging of cellular proliferation with PET is now possible, and has the potential to play an important role in the evaluation of efficacy of new anti-cancer agents.
    Citation
    Positron emission tomography imaging of cell proliferation in oncology. 2004, 16 (3):176-85 Clin Oncol
    Journal
    Clinical Oncology
    URI
    http://hdl.handle.net/10541/78004
    PubMed ID
    15191004
    Type
    Article
    Language
    en
    ISSN
    0936-6555
    Collections
    All Christie Publications

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