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    Pitfalls in the diagnosis of acromegaly.

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    Authors
    Pokrajac, Ana
    Trainer, Peter J
    Affiliation
    Department of Endocrinology, Christie Hospital, Manchester, UK.
    Issue Date
    2004
    
    Metadata
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    Abstract
    Acromegaly is a disfiguring and disabling illness which, when inadequately treated, reduces life expectancy. An implication of the ability to offer effective treatment is the increased onus on physicians of all sorts to ensure acromegaly is diagnosed and treated as early as possible. To this end, criteria for the diagnosis of acromegaly have been proposed in the consensus statement of Giustina et al. However, other data suggest that the proposed criteria are not rigorous enough and strict adherence to the guidelines would result in failure to diagnose a significant number of patients. A review of published experience suggests that the combination of a GH nadir during an oral glucose tolerance test of <0.25 microg/l plus a normal age-related insulin growth factor-I level makes the diagnosis of acromegaly extremely unlikely.
    Citation
    Pitfalls in the diagnosis of acromegaly. 2004, 62 Suppl 3:74-8 Horm. Res.
    Journal
    Hormone Research
    URI
    http://hdl.handle.net/10541/77980
    DOI
    10.1159/000080504
    PubMed ID
    15539804
    Type
    Article
    Language
    en
    ISSN
    0301-0163
    ae974a485f413a2113503eed53cd6c53
    10.1159/000080504
    Scopus Count
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