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dc.contributor.authorGleeson, Helena K
dc.contributor.authorShalet, Stephen M
dc.date.accessioned2009-08-19T16:17:16Z
dc.date.available2009-08-19T16:17:16Z
dc.date.issued2004-12
dc.identifier.citationThe impact of cancer therapy on the endocrine system in survivors of childhood brain tumours. 2004, 11 (4):589-602 Endocr. Relat. Canceren
dc.identifier.issn1351-0088
dc.identifier.pmid15613441
dc.identifier.doi10.1677/erc.1.00779
dc.identifier.urihttp://hdl.handle.net/10541/77927
dc.description.abstractSurvival rates are improving following cancer therapy for childhood brain tumours. There is therefore a growing cohort of survivors at risk of late effects of cancer therapy. Endocrine problems are very common in these patients. The recognition and prompt management of these are essential to prevent further morbidity and impairment of quality of life. Cranial radiation can damage hypothalamic-pituitary function, most frequently affecting GH status; however, higher radiation doses may cause more widespread hypothalamic-pituitary damage. Early puberty secondary to cranial irradiation is now being managed with gonadotrophin-releasing hormone analogues to improve final height. Prompt diagnosis and management of GH deficiency may improve final height outcome; continued GH therapy beyond final height aids the achievement of adult body composition (lean body mass and bone mass) and GH therapy in adulthood improves quality of life. Both cranial irradiation alone and with spinal irradiation can result in radiation damage to the thyroid resulting in hypothyroidism and thyroid nodules, a high proportion of which are malignant. Gonadal damage secondary to spinal irradiation and adjuvant chemotherapy may have long-term consequences including infertility.
dc.language.isoenen
dc.subjectBrain Canceren
dc.subject.meshAdult
dc.subject.meshBrain Neoplasms
dc.subject.meshCardiovascular Diseases
dc.subject.meshChild
dc.subject.meshChild Development
dc.subject.meshChild, Preschool
dc.subject.meshGonads
dc.subject.meshHormones
dc.subject.meshHumans
dc.subject.meshHypothalamo-Hypophyseal System
dc.subject.meshInfant
dc.subject.meshObesity
dc.subject.meshPituitary-Adrenal System
dc.subject.meshPuberty, Precocious
dc.subject.meshRisk Factors
dc.subject.meshSurvivors
dc.subject.meshThyroid Gland
dc.titleThe impact of cancer therapy on the endocrine system in survivors of childhood brain tumours.en
dc.typeArticleen
dc.contributor.departmentDepartment of Endocrinology, Christie Hospital, Manchester M20 4BX, UK. Helena.Gleeson@christie-tr.nwest.nhs.uken
dc.identifier.journalEndocrine-Related Canceren
refterms.dateFOA2020-04-21T08:46:01Z
html.description.abstractSurvival rates are improving following cancer therapy for childhood brain tumours. There is therefore a growing cohort of survivors at risk of late effects of cancer therapy. Endocrine problems are very common in these patients. The recognition and prompt management of these are essential to prevent further morbidity and impairment of quality of life. Cranial radiation can damage hypothalamic-pituitary function, most frequently affecting GH status; however, higher radiation doses may cause more widespread hypothalamic-pituitary damage. Early puberty secondary to cranial irradiation is now being managed with gonadotrophin-releasing hormone analogues to improve final height. Prompt diagnosis and management of GH deficiency may improve final height outcome; continued GH therapy beyond final height aids the achievement of adult body composition (lean body mass and bone mass) and GH therapy in adulthood improves quality of life. Both cranial irradiation alone and with spinal irradiation can result in radiation damage to the thyroid resulting in hypothyroidism and thyroid nodules, a high proportion of which are malignant. Gonadal damage secondary to spinal irradiation and adjuvant chemotherapy may have long-term consequences including infertility.


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