Addition of 18F-FDG-PET scans to radiotherapy planning of thoracic lymphoma.
Authors
Lee, Young KCook, Gary
Flower, Maggie A
Rowbottom, Carl G
Shahidi, Mehdi
Sharma, Bhupinder
Webb, Steve
Affiliation
Joint Department of Physics, Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Downs Road, Sutton, Surrey SM2 5PT, UK.Issue Date
2004-12
Metadata
Show full item recordAbstract
BACKGROUND AND PURPOSE: FDG-PET possesses greater sensitivity and accuracy than computed tomography (CT) in detecting diseased lymph nodes. Though the FDG-PET scans are acquired for similar diagnostic reasons as CT, they are not used in the radiotherapy (RT) planning process. Successful tumourcidal dose is usually delivered but large volumes of normal and non-malignant tissues are irradiated due to the nature of lymphoma and also to the subjectivity of the field determining process. This study tries to lessen the subjectivity of the field determining process by the addition of currently acquired PET to the conventional thoracic lymphoma RT. The differences between retrospectively delineated volumes from CT and FDG-PET were compared and the effect of this additional information was evaluated. MATERIALS AND METHODS: Seventeen FDG-PET scans were registered to corresponding CT scans using rigid-body registration with negligible intra-observer variability. Comparisons were made between the volumes, lateral extensions and the most inferior point of the delineated gross tumour volumes (GTVs). RESULTS: For 1/17 patient data, no diseased volumes were delineated and in 6/17, no volumes were delineated on PET and yet in CT, masses up to 367.2 cm3 were outlined. From the 10 positive-CT and PET data, the GTV(PET) were smaller than GTV(CT) in six cases. Greater than 3.0 cm lateral disease extension differences were observed in 4/10 cases. Inferior tumour extents were confirmed in 6/10 cases whereas in 2/10 patients GTV(CT) was greater than 12.0 cm inferior compared to GTV(PET). CONCLUSIONS: FDG-PET data can be introduced to current thoracic lymphoma RT planning protocol with minimal intervention and changes. The subjectivity in the RT planning of thoracic lymphoma would be decreased with the addition of currently acquired FDG-PET data.Citation
Addition of 18F-FDG-PET scans to radiotherapy planning of thoracic lymphoma. 2004, 73 (3):277-83 Radiother OncolJournal
Radiotherapy and OncologyDOI
10.1016/j.radonc.2004.07.029PubMed ID
15588871Type
ArticleLanguage
enISSN
0167-8140ae974a485f413a2113503eed53cd6c53
10.1016/j.radonc.2004.07.029
Scopus Count
Collections
Related articles
- The contribution of integrated PET/CT to the evolving definition of treatment volumes in radiation treatment planning in lung cancer.
- Authors: Ashamalla H, Rafla S, Parikh K, Mokhtar B, Goswami G, Kambam S, Abdel-Dayem H, Guirguis A, Ross P, Evola A
- Issue date: 2005 Nov 15
- Impact of FDG PET/CT on delineation of the gross tumor volume for radiation planning in non-small-cell lung cancer.
- Authors: Spratt DE, Diaz R, McElmurray J, Csiki I, Duggan D, Lu B, Delbeke D
- Issue date: 2010 Apr
- Prospective feasibility trial of radiotherapy target definition for head and neck cancer using 3-dimensional PET and CT imaging.
- Authors: Scarfone C, Lavely WC, Cmelak AJ, Delbeke D, Martin WH, Billheimer D, Hallahan DE
- Issue date: 2004 Apr
- [¹⁸F]FDG-positron emission tomography coregistration with computed tomography scans for radiation treatment planning of lymphoma and hematologic malignancies.
- Authors: Terezakis SA, Hunt MA, Kowalski A, McCann P, Schmidtlein CR, Reiner A, Gönen M, Kirov AS, Gonzales AM, Schöder H, Yahalom J
- Issue date: 2011 Nov 1
- Reduction of observer variation using matched CT-PET for lung cancer delineation: a three-dimensional analysis.
- Authors: Steenbakkers RJ, Duppen JC, Fitton I, Deurloo KE, Zijp LJ, Comans EF, Uitterhoeve AL, Rodrigus PT, Kramer GW, Bussink J, De Jaeger K, Belderbos JS, Nowak PJ, van Herk M, Rasch CR
- Issue date: 2006 Feb 1