Endocrinology and hormone therapy in breast cancer: aromatase inhibitors versus antioestrogens.
Affiliation
CRUK Department of Medical Oncology, University of Manchester, Christie Hospital, Manchester, UK. maria.parker@christie-tr.nwest.nhs.ukIssue Date
2004
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Endocrine therapies act by either blocking or downregulating the oestrogen receptor or by reducing oestrogen concentrations around and within the cancer cell. In postmenopausal women, oestrogen suppression is achieved by inhibition of the enzyme aromatase by aromatase inhibitors (AIs). Modern AIs (anastrozole, letrozole and exemestane) are more potent than earlier ones and suppress oestradiol levels in plasma to virtually undetectable concentrations. Recent comparisons of AIs with the most widely used oestrogen receptor blocking drug tamoxifen indicate that, in general, AIs result in increased response rates and greater durations of response. Here, we summarize data supporting the difference between the two types of treatment and attempt to account for the underlying mechanisms that favour AIs.Citation
Endocrinology and hormone therapy in breast cancer: aromatase inhibitors versus antioestrogens. 2004, 6 (6):269-74 Breast Cancer Res.Journal
Breast Cancer ResearchDOI
10.1186/bcr945PubMed ID
15535858Type
ArticleLanguage
enISSN
1465-542Xae974a485f413a2113503eed53cd6c53
10.1186/bcr945
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