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    Endocrinology and hormone therapy in breast cancer: aromatase inhibitors versus antioestrogens.

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    Authors
    Howell, Anthony
    Dowsett, Mitch
    Affiliation
    CRUK Department of Medical Oncology, University of Manchester, Christie Hospital, Manchester, UK. maria.parker@christie-tr.nwest.nhs.uk
    Issue Date
    2004
    
    Metadata
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    Abstract
    Endocrine therapies act by either blocking or downregulating the oestrogen receptor or by reducing oestrogen concentrations around and within the cancer cell. In postmenopausal women, oestrogen suppression is achieved by inhibition of the enzyme aromatase by aromatase inhibitors (AIs). Modern AIs (anastrozole, letrozole and exemestane) are more potent than earlier ones and suppress oestradiol levels in plasma to virtually undetectable concentrations. Recent comparisons of AIs with the most widely used oestrogen receptor blocking drug tamoxifen indicate that, in general, AIs result in increased response rates and greater durations of response. Here, we summarize data supporting the difference between the two types of treatment and attempt to account for the underlying mechanisms that favour AIs.
    Citation
    Endocrinology and hormone therapy in breast cancer: aromatase inhibitors versus antioestrogens. 2004, 6 (6):269-74 Breast Cancer Res.
    Journal
    Breast Cancer Research
    URI
    http://hdl.handle.net/10541/77878
    DOI
    10.1186/bcr945
    PubMed ID
    15535858
    Type
    Article
    Language
    en
    ISSN
    1465-542X
    ae974a485f413a2113503eed53cd6c53
    10.1186/bcr945
    Scopus Count
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