Show simple item record

dc.contributor.authorRenehan, Andrew G
dc.contributor.authorAtkin, W S
dc.contributor.authorO'Dwyer, Sarah T
dc.contributor.authorShalet, Stephen M
dc.date.accessioned2009-08-19T13:06:27Z
dc.date.available2009-08-19T13:06:27Z
dc.date.issued2004-10-18
dc.identifier.citationThe effect of cigarette smoking use and cessation on serum insulin-like growth factors. 2004, 91 (8):1525-31 Br. J. Canceren
dc.identifier.issn0007-0920
dc.identifier.pmid15354219
dc.identifier.doi10.1038/sj.bjc.6602150
dc.identifier.urihttp://hdl.handle.net/10541/77874
dc.description.abstractThe patterns of risk association between circulating levels of insulin-like growth factor (IGF)-I, and its main binding protein, IGFBP-3, differ between smoking and nonsmoking-related cancers. To investigate this observation further, we measured serum IGF-I, IGF-II and IGF-binding protein-3 concentrations in 232 men and 210 women (aged 55-64 years), and related peptide levels to smoking characteristics. Current smoking was associated with significant reductions in mean IGFBP-3 levels in men assessed by the number of cigarettes smoked daily (P(trend)=0.007) and pack-years smoked (P(trend)=0.03). Mean IGF-I levels decreased with increasing cigarette use in men (P(trend)=0.11). There were no patterns of association between smoking and IGF peptides in women. For male former vs never smokers, there were no differences in mean IGF-I and IGFBP-3 concentrations, suggesting that smoking cessation is associated with normalisation of peptide concentrations.
dc.language.isoenen
dc.subject.meshCross-Sectional Studies
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshInsulin-Like Growth Factor Binding Protein 3
dc.subject.meshInsulin-Like Growth Factor I
dc.subject.meshInsulin-Like Growth Factor II
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshRisk Factors
dc.subject.meshSmoking
dc.subject.meshSmoking Cessation
dc.titleThe effect of cigarette smoking use and cessation on serum insulin-like growth factors.en
dc.typeArticleen
dc.contributor.departmentDepartment of Surgery, Christie Hospital NHS Trust, Wilmslow Road, Manchester M20 4BX, UK. arenehan@picr.man.ac.uken
dc.identifier.journalBritish Journal of Canceren
html.description.abstractThe patterns of risk association between circulating levels of insulin-like growth factor (IGF)-I, and its main binding protein, IGFBP-3, differ between smoking and nonsmoking-related cancers. To investigate this observation further, we measured serum IGF-I, IGF-II and IGF-binding protein-3 concentrations in 232 men and 210 women (aged 55-64 years), and related peptide levels to smoking characteristics. Current smoking was associated with significant reductions in mean IGFBP-3 levels in men assessed by the number of cigarettes smoked daily (P(trend)=0.007) and pack-years smoked (P(trend)=0.03). Mean IGF-I levels decreased with increasing cigarette use in men (P(trend)=0.11). There were no patterns of association between smoking and IGF peptides in women. For male former vs never smokers, there were no differences in mean IGF-I and IGFBP-3 concentrations, suggesting that smoking cessation is associated with normalisation of peptide concentrations.


This item appears in the following Collection(s)

Show simple item record