Measuring tumor pharmacodynamic response using PET proliferation probes: the case for 2-[(11)C]-thymidine.
Affiliation
Department of Radiotherapy, St. Bartholomews' Hospital, West Smithfield, London EC1A 7BE, UK.Issue Date
2004-12-17
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Show full item recordAbstract
[(18)F]-fluorodeoxyglucose ((18)F-FDG) positron emission tomography (PET) is becoming accepted as a diagnostic tool for cancer, but the potential uses of PET in oncology extend beyond the imaging of glucose metabolism. The development of a PET proliferation probe would be a useful pharmacodynamic tool. [(11)C]-thymidine PET has been assessed in man as a specific measure of tumor proliferation. Uptake of [(11)C]-thymidine is related to DNA synthesis and, in human tumors, correlates with proliferation. When compared with (18)F-FDG, it has been shown to be a more sensitive discriminator of early clinical tumor response. 2-[(11)C]-thymidine PET scanning of patients enrolled in early phase clinical trials is feasible and should support future drug development. Although recent research is moving away from the validation of thymidine towards thymidine analogues radiolabeled with (18)F, the better specificity of thymidine for DNA should be the rationale for its continued development and application as a PET probe. This review describes the historical development, application and current research status of [(11)C]-thymidine PET, and aims to highlight the need for its continuing development as a marker of tumor proliferation.Citation
Measuring tumor pharmacodynamic response using PET proliferation probes: the case for 2-[(11)C]-thymidine. 2004, 1705 (2):91-102 Biochim. Biophys. ActaJournal
Biochimica et Biophysica ActaDOI
10.1016/j.bbcan.2004.09.007PubMed ID
15588764Type
ArticleLanguage
enISSN
0006-3002ae974a485f413a2113503eed53cd6c53
10.1016/j.bbcan.2004.09.007
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