• Login
    View Item 
    •   Home
    • The Christie Research Publications Repository
    • All Christie Publications
    • View Item
    •   Home
    • The Christie Research Publications Repository
    • All Christie Publications
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of ChristieCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsThis CollectionTitleAuthorsIssue DateSubmit DateSubjects

    My Account

    LoginRegister

    Local Links

    The Christie WebsiteChristie Library and Knowledge Service

    Statistics

    Display statistics

    Measuring tumor pharmacodynamic response using PET proliferation probes: the case for 2-[(11)C]-thymidine.

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Authors
    Wells, Paula
    West, Catharine M L
    Jones, Terry
    Harris, Adrian L
    Price, Patricia M
    Affiliation
    Department of Radiotherapy, St. Bartholomews' Hospital, West Smithfield, London EC1A 7BE, UK.
    Issue Date
    2004-12-17
    
    Metadata
    Show full item record
    Abstract
    [(18)F]-fluorodeoxyglucose ((18)F-FDG) positron emission tomography (PET) is becoming accepted as a diagnostic tool for cancer, but the potential uses of PET in oncology extend beyond the imaging of glucose metabolism. The development of a PET proliferation probe would be a useful pharmacodynamic tool. [(11)C]-thymidine PET has been assessed in man as a specific measure of tumor proliferation. Uptake of [(11)C]-thymidine is related to DNA synthesis and, in human tumors, correlates with proliferation. When compared with (18)F-FDG, it has been shown to be a more sensitive discriminator of early clinical tumor response. 2-[(11)C]-thymidine PET scanning of patients enrolled in early phase clinical trials is feasible and should support future drug development. Although recent research is moving away from the validation of thymidine towards thymidine analogues radiolabeled with (18)F, the better specificity of thymidine for DNA should be the rationale for its continued development and application as a PET probe. This review describes the historical development, application and current research status of [(11)C]-thymidine PET, and aims to highlight the need for its continuing development as a marker of tumor proliferation.
    Citation
    Measuring tumor pharmacodynamic response using PET proliferation probes: the case for 2-[(11)C]-thymidine. 2004, 1705 (2):91-102 Biochim. Biophys. Acta
    Journal
    Biochimica et Biophysica Acta
    URI
    http://hdl.handle.net/10541/77869
    DOI
    10.1016/j.bbcan.2004.09.007
    PubMed ID
    15588764
    Type
    Article
    Language
    en
    ISSN
    0006-3002
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.bbcan.2004.09.007
    Scopus Count
    Collections
    All Christie Publications

    entitlement

    Related articles

    • Molecular imaging of proliferation in vivo: positron emission tomography with [18F]fluorothymidine.
    • Authors: Buck AK, Herrmann K, Shen C, Dechow T, Schwaiger M, Wester HJ
    • Issue date: 2009 Jun
    • [(18)F]FLT-PET imaging does not always "light up" proliferating tumor cells.
    • Authors: Zhang CC, Yan Z, Li W, Kuszpit K, Painter CL, Zhang Q, Lappin PB, Nichols T, Lira ME, Affolter T, Fahey NR, Cullinane C, Spilker M, Zasadny K, O'Brien P, Buckman D, Wong A, Christensen JG
    • Issue date: 2012 Mar 1
    • Nucleoside-based probes for imaging tumor proliferation using positron emission tomography.
    • Authors: Alauddin MM
    • Issue date: 2013 Mar-Apr
    • Monitoring response to therapeutic interventions in patients with cancer.
    • Authors: Herrmann K, Krause BJ, Bundschuh RA, Dechow T, Schwaiger M
    • Issue date: 2009 May
    • 3'-deoxy-3'-[18F]fluorothymidine as a new marker for monitoring tumor response to antiproliferative therapy in vivo with positron emission tomography.
    • Authors: Barthel H, Cleij MC, Collingridge DR, Hutchinson OC, Osman S, He Q, Luthra SK, Brady F, Price PM, Aboagye EO
    • Issue date: 2003 Jul 1
    DSpace software (copyright © 2002 - 2023)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.