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    Three distinct subgroups of hypodiploidy in acute lymphoblastic leukaemia.

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    Authors
    Harrison, Christine J
    Moorman, Anthony V
    Broadfield, Zoë J
    Cheung, Kan L
    Harris, Rachel L
    Reza Jalali, G
    Robinson, Hazel M
    Barber, Kerry E
    Richards, Susan M
    Mitchell, Christopher D
    Eden, Tim O B
    Hann, Ian M
    Hill, Frank G H
    Kinsey, Sally E
    Gibson, Brenda E
    Lilleyman, John S
    Vora, Ajay J
    Goldstone, Anthony H
    Franklin, Ian M
    Durrant, I Jill
    Martineau, Mary
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    Affiliation
    Leukaemia Research Fund Cytogenetics Group, Cancer Sciences Division, University of Southampton, Southampton, UK. harrison@soton.ac.uk
    Issue Date
    2004-06
    
    Metadata
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    Abstract
    This study of children and adults with acute lymphoblastic leukaemia (ALL) is the largest series of patients with hypodiploidy (<46 chromosomes) yet reported. The incidence of 5% was independent of age. Patients were subdivided by the number of chromosomes; near-haploidy (23-29 chromosomes), low hypodiploidy (33-39 chromosomes) and high hypodiploidy (42-45 chromosomes). The near-haploid and low hypodiploid groups were characterized by their chromosomal gains and a doubled hyperdiploid population. Structural abnormalities were more frequent in the low hypodiploid group. Near-haploidy was restricted to children of median age 7 years (range 2-15) whereas low hypodiploidy occurred in an older group of median age 15 years (range 9-54). Patients with 42-45 chromosomes were characterized by complex karyotypes involving chromosomes 7, 9 and 12. The features shared by the few patients with 42-44 chromosomes and the large number with 45 justified their inclusion in the same group. Survival analysis showed a poor outcome for the near-haploid and low hypodiploid groups compared to those with 42-45 chromosomes. Thus cytogenetics, or at least a clear definition of the modal chromosome number, is essential at diagnosis in order to stratify patients with hypodiploidy into the appropriate risk group for treatment.
    Citation
    Three distinct subgroups of hypodiploidy in acute lymphoblastic leukaemia. 2004, 125 (5):552-9 Br. J. Haematol.
    Journal
    British Journal of Haematology
    URI
    http://hdl.handle.net/10541/77838
    DOI
    10.1111/j.1365-2141.2004.04948.x
    PubMed ID
    15147369
    Type
    Article
    Language
    en
    ISSN
    0007-1048
    ae974a485f413a2113503eed53cd6c53
    10.1111/j.1365-2141.2004.04948.x
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