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    Stepping into adulthood: the transition period.

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    Authors
    Shalet, Stephen M
    Affiliation
    Christie Hospital NHS Trust, Manchester, UK. stephen.m.shalet@man.ac.uk
    Issue Date
    2004
    
    Metadata
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    Abstract
    The period of growth from late puberty to full adult maturation, termed the transition period, is important for tissue maturation. Peak bone mass, muscle mass and strength are usually attained in this period. However, it is common clinical practice in children with growth hormone deficiency (GHD) to discontinue growth hormone (GH) treatment in adolescence after attainment of final height. Therefore, patients with childhood-onset GHD that continues into adulthood and who do not receive treatment as adults may experience more severe consequences than patients who acquire GHD as an adult. Recent studies indicate that bone and muscle maturation are attenuated if GH treatment is discontinued at final height. Furthermore, these patients will also develop cardiovascular risk factors that are normally associated with GHD in adults. Much debate surrounds when retesting for GHD should be carried out and when GH treatment should be restarted in adolescents; many of these patients will not have severe GHD according to the criteria set for adults. The transition period is an appropriate time to modify GH doses. Finally, registries exist that have recorded clinical treatment experiences for children and adults. Tools that collect and analyse data provide an important opportunity to investigate issues related to transition.
    Citation
    Stepping into adulthood: the transition period. 2004, 62 Suppl 4:15-22 Horm. Res.
    Journal
    Hormone Research
    URI
    http://hdl.handle.net/10541/77836
    DOI
    10.1159/000080904
    PubMed ID
    15591762
    Type
    Article
    Language
    en
    ISSN
    0301-0163
    ae974a485f413a2113503eed53cd6c53
    10.1159/000080904
    Scopus Count
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    All Christie Publications

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