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    Deletion of chromosome arm 15q and hitherto unreported duplication of del(15q) in myeloid disorders.

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    Authors
    Saunders, K
    Williams, Y
    Aldouri, M
    Telford, Nicholas
    Czepulkowski, B
    Affiliation
    Cytogenetics, The Rayne Institute, King's College Hospital, 123 Coldharbour Lane, London SE5 9NU, UK. Karen.Saunders@kingsch.nhs.uk
    Issue Date
    2004-06
    
    Metadata
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    Abstract
    Deletion of the long arm of chromosome 15 has been described as a recurrent chromosomal abnormality in myeloid malignancies. We present here some additional case reports of deletion 15 including two cases with an extra copy of the deleted chromosome, a finding that has not previously been described. We compare our cases to those previously reported. Our findings show that, contrary to previous reports, this abnormality may not always be associated with an unfavorable prognosis. They also indicate that deletion 15q most frequently appears to be associated with myelomonocytic disease. Potential candidate genes on 15q that may be involved in the tumorigenesis of these cases are discussed.
    Citation
    Deletion of chromosome arm 15q and hitherto unreported duplication of del(15q) in myeloid disorders. 2004, 151 (2):146-51 Cancer Genet. Cytogenet.
    Journal
    Cancer Genetics and Cytogenetics
    URI
    http://hdl.handle.net/10541/77799
    DOI
    10.1016/j.cancergencyto.2003.09.016
    PubMed ID
    15172752
    Type
    Article
    Language
    en
    ISSN
    0165-4608
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.cancergencyto.2003.09.016
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