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    Engineering T-cells with antibody-based chimeric receptors for effective cancer therapy.

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    Authors
    Thistlethwaite, Fiona C
    Mansoor, Was
    Gilham, David E
    Hawkins, Robert E
    Affiliation
    Cancer Research UK, Department of Medical Oncology, Christie Research Centre, Manchester, UK.
    Issue Date
    2005-02
    
    Metadata
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    Abstract
    The combination of power and specificity inherent within the immune system make its manipulation an attractive prospect for the development of novel anticancer therapies. However, tumors are frequently poorly recognized by the immune system, and intrinsic controls limit the benefit from active immunization. These and other issues have proved major challenges in the search for effective cancer immunotherapy. Recent advances in the understanding of the immune system and the development of methods to manipulate it have led to the point where engineered T-cell therapy can be tested in the clinical setting with a realistic chance of success. These advances are considered and potential future clinical and scientific issues involved in the successful development of effective, engineered T-cell therapy are examined.
    Citation
    Engineering T-cells with antibody-based chimeric receptors for effective cancer therapy. 2005, 7 (1):48-55 Curr. Opin. Mol. Ther.
    Journal
    Current Opinion in Molecular Therapeutics
    URI
    http://hdl.handle.net/10541/76829
    PubMed ID
    15732529
    Type
    Article
    Language
    en
    ISSN
    1464-8431
    Collections
    All Christie Publications
    All Paterson Institute for Cancer Research

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