• Login
    View Item 
    •   Home
    • The Christie Research Publications Repository
    • All Christie Publications
    • View Item
    •   Home
    • The Christie Research Publications Repository
    • All Christie Publications
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of ChristieCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsThis CollectionTitleAuthorsIssue DateSubmit DateSubjects

    My Account

    LoginRegister

    Local Links

    The Christie WebsiteChristie Library and Knowledge Service

    Statistics

    Display statistics

    Molecular markers predicting radiotherapy response: report and recommendations from an International Atomic Energy Agency technical meeting.

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Authors
    West, Catharine M L
    McKay, Michael J
    Hölscher, Tobias
    Baumann, Michael
    Stratford, Ian J
    Bristow, Robert G
    Iwakawa, Mayumi
    Imai, Takashi
    Zingde, Surekha M
    Anscher, Mitchell S
    Bourhis, Jean
    Begg, Adrian C
    Haustermans, Karin
    Bentzen, Soren M
    Hendry, Jolyon H
    Show allShow less
    Affiliation
    Academic Department of Radiation Oncology, The University of Manchester, Christie Hospital NHS Trust, Withington, Manchester, UK.
    Issue Date
    2005-08-01
    
    Metadata
    Show full item record
    Abstract
    PURPOSE: There is increasing interest in radiogenomics and the characterization of molecular profiles that predict normal tissue and tumor radioresponse. A meeting in Amsterdam was organized by the International Atomic Energy Agency to discuss this topic on an international basis. METHODS AND MATERIALS: This report is not completely exhaustive, but highlights some of the ongoing studies and new initiatives being carried out worldwide in the banking of tumor and normal tissue samples underpinning the development of molecular marker profiles for predicting patient response to radiotherapy. It is generally considered that these profiles will more accurately define individual or group radiosensitivities compared with the nondefinitive findings from the previous era of cellular-based techniques. However, so far there are only a few robust reports of molecular markers predicting normal tissue or tumor response. RESULTS: Many centers in different countries have initiated tissue and tumor banks to store samples from clinical trials for future molecular profiling analysis, to identify profiles that predict for radiotherapy response. The European Society for Therapeutic Radiology and Oncology GENEtic pathways for the Prediction of the effects of Irradiation (GENEPI) project, to store, document, and analyze sample characteristics vs. response, is the most comprehensive in this regard. CONCLUSIONS: The next 5-10 years are likely to see the results of these and other correlative studies, and promising associations of profiles with response should be validated in larger definitive trials.
    Citation
    Molecular markers predicting radiotherapy response: report and recommendations from an International Atomic Energy Agency technical meeting. 2005, 62 (5):1264-73 Int. J. Radiat. Oncol. Biol. Phys.
    Journal
    International Journal of Radiation Oncology, Biology, Physics
    URI
    http://hdl.handle.net/10541/76801
    DOI
    10.1016/j.ijrobp.2005.05.001
    PubMed ID
    16029781
    Type
    Article
    Language
    en
    ISSN
    0360-3016
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.ijrobp.2005.05.001
    Scopus Count
    Collections
    All Christie Publications

    entitlement

    Related articles

    • [Biochemical markers predicting response to radiation- and radiochemo-therapy in cancer patients].
    • Authors: Ivanov SD
    • Issue date: 2012 Nov-Dec
    • Modeling Cellular Response in Large-Scale Radiogenomic Databases to Advance Precision Radiotherapy.
    • Authors: Manem VS, Lambie M, Smith I, Smirnov P, Kofia V, Freeman M, Koritzinsky M, Abazeed ME, Haibe-Kains B, Bratman SV
    • Issue date: 2019 Dec 15
    • Adverse event reporting and developments in radiation biology after normal tissue injury: International Atomic Energy Agency consultation.
    • Authors: Chen Y, Trotti A, Coleman CN, Machtay M, Mirimanoff RO, Hay J, O'brien PC, El-Gueddari B, Salvajoli JV, Jeremic B
    • Issue date: 2006 Apr 1
    • First report on the patient database for the identification of the genetic pathways involved in patients over-reacting to radiotherapy: GENEPI-II.
    • Authors: De Ruysscher D, Severin D, Barnes E, Baumann M, Bristow R, Grégoire V, Hölscher T, Veninga T, Polański A, van Veen EB, Verfaillie C, Heeren G, Damaraju S, Just U, Haustermans K
    • Issue date: 2010 Oct
    • Can risk of radiotherapy-induced normal tissue complications be predicted from genetic profiles?
    • Authors: Andreassen CN
    • Issue date: 2005
    DSpace software (copyright © 2002 - 2023)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.