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dc.contributor.authorRoulson, Jo-an
dc.contributor.authorBenbow, E W
dc.contributor.authorHasleton, Philip S
dc.date.accessioned2009-08-10T10:50:24Z
dc.date.available2009-08-10T10:50:24Z
dc.date.issued2005-12
dc.identifier.citationDiscrepancies between clinical and autopsy diagnosis and the value of post mortem histology; a meta-analysis and review. 2005, 47 (6):551-9 Histopathologyen
dc.identifier.issn0309-0167
dc.identifier.pmid16324191
dc.identifier.doi10.1111/j.1365-2559.2005.02243.x
dc.identifier.urihttp://hdl.handle.net/10541/76784
dc.description.abstractThe autopsy is in decline, despite the fact that accurate mortality statistics remain essential for public health and health service planning. The falling autopsy rate combined with the Coroners Review and Human Tissue Act have contributed to this decline, and to a falling use of autopsy histology, with potential impact on clinical audit and mortality statistics. At a time when the need for reform and improvement in the death certification process is so prominent, we felt it important to assess the value of the autopsy and autopsy histology. We carried out a meta-analysis of discrepancies between clinical and autopsy diagnoses and the contribution of autopsy histology. There has been little improvement in the overall rate of discrepancies between the 1960s and the present. At least a third of death certificates are likely to be incorrect and 50% of autopsies produce findings unsuspected before death. In addition, the cases which give rise to discrepancies cannot be identified prior to autopsy. Over 20% of clinically unexpected autopsy findings, including 5% of major findings, can be correctly diagnosed only by histological examination. Although the autopsy and particularly autopsy histology are being undermined, they are still the most accurate method of determining the cause of death and auditing accuracy of clinical diagnosis, diagnostic tests and death certification.
dc.language.isoenen
dc.subject.meshAge Distribution
dc.subject.meshAutopsy
dc.subject.meshCause of Death
dc.subject.meshDeath Certificates
dc.subject.meshDiagnosis
dc.subject.meshDiagnostic Errors
dc.subject.meshFemale
dc.subject.meshHistology
dc.subject.meshHumans
dc.subject.meshMale
dc.subject.meshRetrospective Studies
dc.subject.meshSensitivity and Specificity
dc.titleDiscrepancies between clinical and autopsy diagnosis and the value of post mortem histology; a meta-analysis and review.en
dc.typeArticleen
dc.contributor.departmentDepartment of Histopathology, Christie Hospital, Manchester, UK. jroulson@picr.man.ac.uken
dc.identifier.journalHistopathologyen
html.description.abstractThe autopsy is in decline, despite the fact that accurate mortality statistics remain essential for public health and health service planning. The falling autopsy rate combined with the Coroners Review and Human Tissue Act have contributed to this decline, and to a falling use of autopsy histology, with potential impact on clinical audit and mortality statistics. At a time when the need for reform and improvement in the death certification process is so prominent, we felt it important to assess the value of the autopsy and autopsy histology. We carried out a meta-analysis of discrepancies between clinical and autopsy diagnoses and the contribution of autopsy histology. There has been little improvement in the overall rate of discrepancies between the 1960s and the present. At least a third of death certificates are likely to be incorrect and 50% of autopsies produce findings unsuspected before death. In addition, the cases which give rise to discrepancies cannot be identified prior to autopsy. Over 20% of clinically unexpected autopsy findings, including 5% of major findings, can be correctly diagnosed only by histological examination. Although the autopsy and particularly autopsy histology are being undermined, they are still the most accurate method of determining the cause of death and auditing accuracy of clinical diagnosis, diagnostic tests and death certification.


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