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dc.contributor.authorMenasce, Lia P
dc.contributor.authorShanks, Jonathan H
dc.contributor.authorHowarth, V S
dc.contributor.authorBanerjee, Saumitra S
dc.date.accessioned2009-08-10T10:26:59Z
dc.date.available2009-08-10T10:26:59Z
dc.date.issued2005-07
dc.identifier.citationRegressed cutaneous malignant melanoma mimicking lymphoma: a potential diagnostic pitfall. 2005, 13 (3):281-4 Int. J. Surg. Pathol.en
dc.identifier.issn1066-8969
dc.identifier.pmid16086086
dc.identifier.urihttp://hdl.handle.net/10541/76780
dc.description.abstractWe report 2 cases of partially regressed malignant melanoma in which the brisk lymphocytic response closely resembled mycosis fungoides in 1 case and nodular sclerosing Hodgkin lymphoma in the other. Striking epidermotropism was present in both cases. The lymphocytes were predominantly of T8 cytotoxic subtype, and oligoclonal T-cell expansion was detected in 1 of the cases. The scanty residual melanoma cells were highlighted with HMB45 and S100 protein. We highlight the features of regression in melanoma that may lead to an erroneous diagnosis of lymphoma and discuss the finding of oligoclonal T-cell expansion in regressed melanocytic lesions.
dc.language.isoenen
dc.subjectCancer Regressionen
dc.subjectSkin Canceren
dc.subjectTumour Markersen
dc.subject.meshAged
dc.subject.meshAged, 80 and over
dc.subject.meshClone Cells
dc.subject.meshDNA, Neoplasm
dc.subject.meshDiagnosis, Differential
dc.subject.meshDiagnostic Errors
dc.subject.meshFemale
dc.subject.meshHodgkin Disease
dc.subject.meshHumans
dc.subject.meshMelanoma
dc.subject.meshMiddle Aged
dc.subject.meshMycosis Fungoides
dc.subject.meshNeoplasm Regression, Spontaneous
dc.subject.meshSkin Neoplasms
dc.subject.meshT-Lymphocyte Subsets
dc.subject.meshTumor Markers, Biological
dc.titleRegressed cutaneous malignant melanoma mimicking lymphoma: a potential diagnostic pitfall.en
dc.typeArticleen
dc.contributor.departmentDepartment of Pathology, Christie Hospital NHS Trust, Withington, Manchester, UK.en
dc.identifier.journalInternational Journal of Surgical Pathologyen
html.description.abstractWe report 2 cases of partially regressed malignant melanoma in which the brisk lymphocytic response closely resembled mycosis fungoides in 1 case and nodular sclerosing Hodgkin lymphoma in the other. Striking epidermotropism was present in both cases. The lymphocytes were predominantly of T8 cytotoxic subtype, and oligoclonal T-cell expansion was detected in 1 of the cases. The scanty residual melanoma cells were highlighted with HMB45 and S100 protein. We highlight the features of regression in melanoma that may lead to an erroneous diagnosis of lymphoma and discuss the finding of oligoclonal T-cell expansion in regressed melanocytic lesions.


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