Affiliation
Department of Endocrinology, Christie Hospital, Manchester, England.Issue Date
2005-10
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Show full item recordAbstract
Pegvisomant is a pegylated analog of growth that functions as a growth hormone receptor antagonist. The drug is capable of normalizing serum IGF-I concentrations (the chief mediator of disease activity in acromegaly) in 97% of patients, and therapy is associated with significant improvements in the symptoms and signs of GH excess. Biochemical control may be achieved with pegvisomant in patients wholly or partially resistant to somatostatin analogs, and there are emerging data to suggest that the drug may be particularly suitable for patients with acromegaly and co-existent diabetes mellitus.Citation
Treatment of pituitary tumors: pegvisomant. 2005, 28 (1):111-4 EndocrineJournal
EndocrineDOI
10.1385/ENDO:28:1:111PubMed ID
16311417Type
ArticleLanguage
enISSN
0969-711Xae974a485f413a2113503eed53cd6c53
10.1385/ENDO:28:1:111
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