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    Treatment of pituitary tumors: pegvisomant.

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    Authors
    Paisley, Angela N
    Drake, William M
    Affiliation
    Department of Endocrinology, Christie Hospital, Manchester, England.
    Issue Date
    2005-10
    
    Metadata
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    Abstract
    Pegvisomant is a pegylated analog of growth that functions as a growth hormone receptor antagonist. The drug is capable of normalizing serum IGF-I concentrations (the chief mediator of disease activity in acromegaly) in 97% of patients, and therapy is associated with significant improvements in the symptoms and signs of GH excess. Biochemical control may be achieved with pegvisomant in patients wholly or partially resistant to somatostatin analogs, and there are emerging data to suggest that the drug may be particularly suitable for patients with acromegaly and co-existent diabetes mellitus.
    Citation
    Treatment of pituitary tumors: pegvisomant. 2005, 28 (1):111-4 Endocrine
    Journal
    Endocrine
    URI
    http://hdl.handle.net/10541/76355
    DOI
    10.1385/ENDO:28:1:111
    PubMed ID
    16311417
    Type
    Article
    Language
    en
    ISSN
    0969-711X
    ae974a485f413a2113503eed53cd6c53
    10.1385/ENDO:28:1:111
    Scopus Count
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