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dc.contributor.authorClarke, Robert B
dc.contributor.authorBundred, Nigel J
dc.date.accessioned2009-08-04T17:31:13Z
dc.date.available2009-08-04T17:31:13Z
dc.date.issued2005
dc.identifier.citationDo early premalignant changes in normal breast epithelial cells predict cancer development? 2005, 7 (1):18-20 Breast Cancer Res.en
dc.identifier.issn1465-542X
dc.identifier.pmid15642177
dc.identifier.doi10.1186/bcr967
dc.identifier.urihttp://hdl.handle.net/10541/76284
dc.description.abstractA recent report suggests that, in an in vitro model of premalignant breast cells (vHMECs), silencing of INK4A gene is accompanied by over-expression of cyclo-oxygenase (COX)-2. This suggests that COX-2 over-expression may be an early event in breast cancer aetiology permitting clones within the normal epithelium to evade apoptosis, to increase their numbers and perhaps acquire further changes that promote the formation of hyperplasias, and eventually carcinomas. While COX-2 expression in normal breast epithelium in vivo has not been proven to be linked to an increased risk of breast cancer, its over-expression in the premalignant model in vitro does provide preliminary evidence that COX-2 inhibition may be a useful chemoprevention strategy.
dc.language.isoenen
dc.subjectBreast Canceren
dc.subjectCancer Invasivenessen
dc.subject.meshApoptosis
dc.subject.meshBreast Neoplasms
dc.subject.meshCell Transformation, Neoplastic
dc.subject.meshCyclin-Dependent Kinase Inhibitor p16
dc.subject.meshCyclooxygenase 2
dc.subject.meshCyclooxygenase Inhibitors
dc.subject.meshEpithelial Cells
dc.subject.meshFemale
dc.subject.meshGene Silencing
dc.subject.meshHumans
dc.subject.meshHyperplasia
dc.subject.meshNeoplasm Invasiveness
dc.subject.meshPrecancerous Conditions
dc.subject.meshRisk Factors
dc.titleDo early premalignant changes in normal breast epithelial cells predict cancer development?en
dc.typeArticleen
dc.contributor.departmentCR-UK Department of Medical Oncology, University of Manchester, Christie Hospital NHS Trust, Manchester, UK.en
dc.identifier.journalBreast Cancer Researchen
html.description.abstractA recent report suggests that, in an in vitro model of premalignant breast cells (vHMECs), silencing of INK4A gene is accompanied by over-expression of cyclo-oxygenase (COX)-2. This suggests that COX-2 over-expression may be an early event in breast cancer aetiology permitting clones within the normal epithelium to evade apoptosis, to increase their numbers and perhaps acquire further changes that promote the formation of hyperplasias, and eventually carcinomas. While COX-2 expression in normal breast epithelium in vivo has not been proven to be linked to an increased risk of breast cancer, its over-expression in the premalignant model in vitro does provide preliminary evidence that COX-2 inhibition may be a useful chemoprevention strategy.


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