• Login
    View Item 
    •   Home
    • The Manchester Institute Cancer Research UK
    • All Paterson Institute for Cancer Research
    • View Item
    •   Home
    • The Manchester Institute Cancer Research UK
    • All Paterson Institute for Cancer Research
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of ChristieCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsThis CollectionTitleAuthorsIssue DateSubmit DateSubjects

    My Account

    LoginRegister

    Local Links

    The Christie WebsiteChristie Library and Knowledge Service

    Statistics

    Display statistics

    Do early premalignant changes in normal breast epithelial cells predict cancer development?

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Authors
    Clarke, Robert B
    Bundred, Nigel J
    Affiliation
    CR-UK Department of Medical Oncology, University of Manchester, Christie Hospital NHS Trust, Manchester, UK.
    Issue Date
    2005
    
    Metadata
    Show full item record
    Abstract
    A recent report suggests that, in an in vitro model of premalignant breast cells (vHMECs), silencing of INK4A gene is accompanied by over-expression of cyclo-oxygenase (COX)-2. This suggests that COX-2 over-expression may be an early event in breast cancer aetiology permitting clones within the normal epithelium to evade apoptosis, to increase their numbers and perhaps acquire further changes that promote the formation of hyperplasias, and eventually carcinomas. While COX-2 expression in normal breast epithelium in vivo has not been proven to be linked to an increased risk of breast cancer, its over-expression in the premalignant model in vitro does provide preliminary evidence that COX-2 inhibition may be a useful chemoprevention strategy.
    Citation
    Do early premalignant changes in normal breast epithelial cells predict cancer development? 2005, 7 (1):18-20 Breast Cancer Res.
    Journal
    Breast Cancer Research
    URI
    http://hdl.handle.net/10541/76284
    DOI
    10.1186/bcr967
    PubMed ID
    15642177
    Type
    Article
    Language
    en
    ISSN
    1465-542X
    ae974a485f413a2113503eed53cd6c53
    10.1186/bcr967
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

    entitlement

    Related articles

    • Hypermethylation of 14-3-3 sigma (stratifin) is an early event in breast cancer.
    • Authors: Umbricht CB, Evron E, Gabrielson E, Ferguson A, Marks J, Sukumar S
    • Issue date: 2001 Jun 7
    • Up and downregulation of p16(Ink4a) expression in BRAF-mutated polyps/adenomas indicates a senescence barrier in the serrated route to colon cancer.
    • Authors: Kriegl L, Neumann J, Vieth M, Greten FR, Reu S, Jung A, Kirchner T
    • Issue date: 2011 Jul
    • Morphologically normal-appearing mammary epithelial cells obtained from high-risk women exhibit methylation silencing of INK4a/ARF.
    • Authors: Bean GR, Bryson AD, Pilie PG, Goldenberg V, Baker JC Jr, Ibarra C, Brander DM, Paisie C, Case NR, Gauthier M, Reynolds PA, Dietze E, Ostrander J, Scott V, Wilke LG, Yee L, Kimler BF, Fabian CJ, Zalles CM, Broadwater G, Tlsty TD, Seewaldt VL
    • Issue date: 2007 Nov 15
    • p38 regulates cyclooxygenase-2 in human mammary epithelial cells and is activated in premalignant tissue.
    • Authors: Gauthier ML, Pickering CR, Miller CJ, Fordyce CA, Chew KL, Berman HK, Tlsty TD
    • Issue date: 2005 Mar 1
    • Mechanisms underlying the growth inhibitory effects of the cyclo-oxygenase-2 inhibitor celecoxib in human breast cancer cells.
    • Authors: Basu GD, Pathangey LB, Tinder TL, Gendler SJ, Mukherjee P
    • Issue date: 2005
    DSpace software (copyright © 2002 - 2023)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.