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    Toward personalized immunotherapy for non-Hodgkin lymphoma: targeting the idiotypic immunoglobulin.

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    Authors
    Armstrong, Anne C
    Cheadle, Eleanor J
    Hawkins, Robert E
    Affiliation
    Cancer Research UK Department of Medical Oncology, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester, UK.
    Issue Date
    2005
    
    Metadata
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    Abstract
    The idiotypic determinants of B-cell lymphomas, formed by cell-specific rearrangement of the immunoglobulin genes, are unique and are therefore a suitable target against which to direct immunotherapy. Recent advances in our understanding of the fundamental mechanisms behind an effective immune response, coupled with advances in genetic engineering techniques, have led to a renewed interest in immunotherapy. Early clinical studies have confirmed the immunogenicity of the idiotypic antigen in patients with lymphoma. This review discusses the different methods of idiotypic vaccination currently under investigation in the clinic, including protein, genetic, and cellular vaccines. Protein vaccines are the most clinically advanced, with phase III trials of idiotypic protein linked to GM-CSF currently underway. DNA vaccines are easier to produce but to date only appear to be weakly immunogenic in man. Dendritic cell vaccines have shown promise but their use may be limited by the complexity of this approach. This review also highlights other approaches not yet in the clinic but that have shown promise in the laboratory, such as viral vaccines and T-cell therapy.
    Citation
    Toward personalized immunotherapy for non-Hodgkin lymphoma: targeting the idiotypic immunoglobulin. 2005, 19 (5):289-97 BioDrugs
    Journal
    BioDrugs
    URI
    http://hdl.handle.net/10541/76273
    PubMed ID
    16207070
    Type
    Article
    Language
    en
    ISSN
    1173-8804
    Collections
    All Paterson Institute for Cancer Research

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