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dc.contributor.authorAnsell, Pat
dc.contributor.authorMitchell, Christopher D
dc.contributor.authorRoman, Eve
dc.contributor.authorSimpson, Jill
dc.contributor.authorBirch, Jillian M
dc.contributor.authorEden, Tim O B
dc.date.accessioned2009-07-29T13:47:52Z
dc.date.available2009-07-29T13:47:52Z
dc.date.issued2005-03
dc.identifier.citationRelationships between perinatal and maternal characteristics and hepatoblastoma: a report from the UKCCS. 2005, 41 (5):741-8 Eur. J. Canceren
dc.identifier.issn0959-8049
dc.identifier.pmid15763651
dc.identifier.doi10.1016/j.ejca.2004.10.024
dc.identifier.urihttp://hdl.handle.net/10541/75861
dc.description.abstractWithin the context of a national population-based case-control study--the United Kingdom Childhood Cancer Study (UKCCS)--we aimed to explore relationships between perinatal and maternal factors and childhood hepatic tumours, for participants with data available from medical records. 26/28 children with hepatic tumours (22/24 hepatoblastomas, 4/4 hepatocellular carcinomas (HCC)) and 4753 age- and sex-matched controls were included. Polyhydramnios was associated with 0.9% of control pregnancies and 13.6% of case pregnancies (Odds Ratio (OR)=28.64, 95% Confidence Interval (CI)=6.94-118.21, P<0.0001); eclampsia or severe pre-eclampsia complicated the pregnancies of 16.7% of mothers whose children developed hepatoblastoma compared with 0.5% of control pregnancies (OR=52.50, 95% CI=10.75-257.05, P<0.0001). Three children with hepatoblastoma weighed <1500 g at birth, two of whom weighed <1000 g (OR for birthweight <1500 g=69.00, 95% CI=11.98-397.17, P<0.0001). Of children with hepatoblastoma, 50% (11/22) had records of congenital anomalies, as did two of their mothers. Three mothers of children with hepatoblastoma had diagnoses of cancer--two of papillary carcinoma of the thyroid and one of acute lymphoblastic leukaemia (ALL). Paediatricians and others should be alert to the possibility of familial or genetic syndromes in children with hepatoblastomas. Potential links between maternal pre-eclampsia, low birthweight and subsequent malignancy merit further investigation. Hepatoblastoma is an extremely rare childhood tumour, but understanding the mechanism(s) underlying severe pre-eclampsia and eclampsia may also shed light on factors that contribute to the development of hepatoblastoma.
dc.language.isoenen
dc.subjectLiver Canceren
dc.subjectHaepatoblastomaen
dc.subject.meshCarcinoma, Hepatocellular
dc.subject.meshCase-Control Studies
dc.subject.meshChild
dc.subject.meshChild, Preschool
dc.subject.meshConfidence Intervals
dc.subject.meshFemale
dc.subject.meshHepatoblastoma
dc.subject.meshHumans
dc.subject.meshInfant
dc.subject.meshInfant, Low Birth Weight
dc.subject.meshInfant, Newborn
dc.subject.meshLiver Neoplasms
dc.subject.meshMale
dc.subject.meshOdds Ratio
dc.subject.meshPregnancy
dc.subject.meshPregnancy Complications
dc.titleRelationships between perinatal and maternal characteristics and hepatoblastoma: a report from the UKCCS.en
dc.typeArticleen
dc.contributor.departmentLeukaemia Research Fund Epidemiology and Genetics Unit, Department of Health Sciences, Seebohm Rowntree Building, University of York, York YO10 5DD, UK. pat.ansell@egu.york.ac.uken
dc.identifier.journalEuropean Journal of Canceren
html.description.abstractWithin the context of a national population-based case-control study--the United Kingdom Childhood Cancer Study (UKCCS)--we aimed to explore relationships between perinatal and maternal factors and childhood hepatic tumours, for participants with data available from medical records. 26/28 children with hepatic tumours (22/24 hepatoblastomas, 4/4 hepatocellular carcinomas (HCC)) and 4753 age- and sex-matched controls were included. Polyhydramnios was associated with 0.9% of control pregnancies and 13.6% of case pregnancies (Odds Ratio (OR)=28.64, 95% Confidence Interval (CI)=6.94-118.21, P<0.0001); eclampsia or severe pre-eclampsia complicated the pregnancies of 16.7% of mothers whose children developed hepatoblastoma compared with 0.5% of control pregnancies (OR=52.50, 95% CI=10.75-257.05, P<0.0001). Three children with hepatoblastoma weighed <1500 g at birth, two of whom weighed <1000 g (OR for birthweight <1500 g=69.00, 95% CI=11.98-397.17, P<0.0001). Of children with hepatoblastoma, 50% (11/22) had records of congenital anomalies, as did two of their mothers. Three mothers of children with hepatoblastoma had diagnoses of cancer--two of papillary carcinoma of the thyroid and one of acute lymphoblastic leukaemia (ALL). Paediatricians and others should be alert to the possibility of familial or genetic syndromes in children with hepatoblastomas. Potential links between maternal pre-eclampsia, low birthweight and subsequent malignancy merit further investigation. Hepatoblastoma is an extremely rare childhood tumour, but understanding the mechanism(s) underlying severe pre-eclampsia and eclampsia may also shed light on factors that contribute to the development of hepatoblastoma.


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