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dc.contributor.authorCortesi, Enrico
dc.contributor.authorGascon, Pere
dc.contributor.authorHenry, David
dc.contributor.authorLittlewood, Timothy
dc.contributor.authorMilroy, Robert
dc.contributor.authorPronzato, Paolo
dc.contributor.authorReinhardt, Uwe
dc.contributor.authorShasha, Daniel
dc.contributor.authorThatcher, Nick
dc.contributor.authorWilkinson, Peter M
dc.date.accessioned2009-07-29T12:39:38Z
dc.date.available2009-07-29T12:39:38Z
dc.date.issued2005
dc.identifier.citationStandard of care for cancer-related anemia: improving hemoglobin levels and quality of life. 2005, 68 Suppl 1:22-32 Oncologyen
dc.identifier.issn0030-2414
dc.identifier.pmid15855813
dc.identifier.doi10.1159/000083130
dc.identifier.urihttp://hdl.handle.net/10541/75853
dc.description.abstractThe introduction of recombinant human erythropoietin (rHuEPO) has proven to be a major advance in the therapeutic options available for managing anemia in cancer patients. The results of placebo-controlled clinical trials and large, community-based, open-label studies have confirmed that epoetin alfa, a recombinant human erythropoietin, significantly reduces transfusion requirements, and reliably increases hemoglobin (Hb) levels in anemic (Hb level <12 g/dl) cancer patients undergoing chemotherapy. Increased Hb improves patients' energy level and their ability to perform the activities of daily living, as well as their overall quality of life (QOL). These findings are independent of tumor type and disease status and are comparable in patients receiving nonplatinum- and platinum-based chemotherapeutic regimens. Furthermore, more than a decade of use in clinical trials and by physicians in routine clinical practice has demonstrated that epoetin alfa is safe and well tolerated when used to treat cancer patients with anemia. The availability of epoetin alfa as an alternative to transfusion has changed practices in anemia management; physicians can now treat anemia with the goal of achieving adequate Hb levels to relieve anemia-related fatigue, a major symptom contributing to decreased QOL in cancer patients. Incremental benefit analysis has shown that increasing Hb level from 11 g/dl to 12 g/dl yields the greatest improvement in QOL per 1 g/dl increase in Hb. The demonstrated efficacy of epoetin alfa for increasing Hb levels and improving patient QOL have made this agent a rationale choice for management of cancer-related anemia. Ongoing research will continue to provide new insights into best management of anemia with epoetin alfa in cancer patients.
dc.language.isoenen
dc.subjectAnaemiaen
dc.subjectHaematinicsen
dc.subjectHaemoglobinsen
dc.subjectCanceren
dc.subject.meshAnemia, Hypochromic
dc.subject.meshControlled Clinical Trials as Topic
dc.subject.meshEpoetin Alfa
dc.subject.meshErythropoietin, Recombinant
dc.subject.meshHematinics
dc.subject.meshHemoglobins
dc.subject.meshHumans
dc.subject.meshNeoplasms
dc.subject.meshQuality of Life
dc.subject.meshSeverity of Illness Index
dc.titleStandard of care for cancer-related anemia: improving hemoglobin levels and quality of life.en
dc.typeArticleen
dc.contributor.departmentDipartimento Medicina Sperimentale e Patologia, Università di Roma, Rome, Italy.en
dc.identifier.journalOncologyen
html.description.abstractThe introduction of recombinant human erythropoietin (rHuEPO) has proven to be a major advance in the therapeutic options available for managing anemia in cancer patients. The results of placebo-controlled clinical trials and large, community-based, open-label studies have confirmed that epoetin alfa, a recombinant human erythropoietin, significantly reduces transfusion requirements, and reliably increases hemoglobin (Hb) levels in anemic (Hb level <12 g/dl) cancer patients undergoing chemotherapy. Increased Hb improves patients' energy level and their ability to perform the activities of daily living, as well as their overall quality of life (QOL). These findings are independent of tumor type and disease status and are comparable in patients receiving nonplatinum- and platinum-based chemotherapeutic regimens. Furthermore, more than a decade of use in clinical trials and by physicians in routine clinical practice has demonstrated that epoetin alfa is safe and well tolerated when used to treat cancer patients with anemia. The availability of epoetin alfa as an alternative to transfusion has changed practices in anemia management; physicians can now treat anemia with the goal of achieving adequate Hb levels to relieve anemia-related fatigue, a major symptom contributing to decreased QOL in cancer patients. Incremental benefit analysis has shown that increasing Hb level from 11 g/dl to 12 g/dl yields the greatest improvement in QOL per 1 g/dl increase in Hb. The demonstrated efficacy of epoetin alfa for increasing Hb levels and improving patient QOL have made this agent a rationale choice for management of cancer-related anemia. Ongoing research will continue to provide new insights into best management of anemia with epoetin alfa in cancer patients.


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