Platelet-derived growth factor receptor (PDGFR): a target for anticancer therapeutics.
Affiliation
Cancer Research UK Department Medical Oncology, Christie Hospital, Manchester M20 4BX, UK. Ruth.Board@christie-tr.nwest.nhs.ukIssue Date
2005
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Platelet-derived growth factors (PDGFs) and their tyrosine kinase receptors (PDGFRs) have been implicated in the pathogenesis of a number of tumor types and play an important role in angiogenesis. Tumor growth can be promoted by PDGF via autocrine stimulation of malignant cells, by overexpression or overactivation of PDGFRs, or by stimulation of angiogenesis within the tumor. These mechanisms could provide possible therapeutic targets. PDGFR blockade may also lower the interstitial fluid pressure within solid tumors and enhance drug delivery. Here we discuss the possible therapeutic roles of PDGFR antagonists in the treatment of cancer, alone and in combination with chemotherapy or other targeted agents. Extensive experimental data highlight the potential therapeutic advantage of targeting PDGFR. However, recent clinical data suggest that antagonism of this growth factor is associated with fluid accumulation that could obscure any clinical benefit. Further clinical research is required to optimise inhibition of this cytokine-receptor system.Citation
Platelet-derived growth factor receptor (PDGFR): a target for anticancer therapeutics., 8 (1-2):75-83 Drug Resist. Updat.Journal
Drug Resistance UpdatesDOI
10.1016/j.drup.2005.03.004PubMed ID
15939344Type
ArticleLanguage
enISSN
1368-7646ae974a485f413a2113503eed53cd6c53
10.1016/j.drup.2005.03.004
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