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dc.contributor.authorEvans, D Gareth R
dc.contributor.authorLalloo, Fiona
dc.contributor.authorHopwood, Penelope
dc.contributor.authorMaurice, Andrew
dc.contributor.authorBaildam, Andrew D
dc.contributor.authorBrain, Anne
dc.contributor.authorBarr, Lester
dc.contributor.authorHowell, Anthony
dc.date.accessioned2009-07-29T12:04:20Z
dc.date.available2009-07-29T12:04:20Z
dc.date.issued2005-12
dc.identifier.citationSurgical decisions made by 158 women with hereditary breast cancer aged <50 years. 2005, 31 (10):1112-8 Eur J Surg Oncolen
dc.identifier.issn0748-7983
dc.identifier.pmid16005602
dc.identifier.doi10.1016/j.ejso.2005.05.007
dc.identifier.urihttp://hdl.handle.net/10541/75825
dc.description.abstractAIM: To establish the uptake of contralateral risk reducing mastectomy in women informed of their risks and options at time of diagnosis of their primary unilateral breast cancer. METHODS: We have assessed the surgical choices of 70 women diagnosed with breast cancer <50 years as part of a family history surveillance program and fully informed about their contralateral risks and surgical options. We have compared this to women from other surgical clinics who were subsequently found to harbour a pathogenic BRCA1/2 mutation. RESULTS: Sixty-five percent (13/20) of BRCA1/2 mutation carriers and 59% (n=20/34) of those at the highest level of risk pre-diagnosis (33+% lifetime risk) opted for contra-lateral mastectomy in the study sample. In contrast only 10% (n=9/88) women identified as mutation carriers from other clinics opted for such surgery. CONCLUSIONS: We would suggest that women with a significant family history and therefore a high contra-lateral breast cancer risk, should have these risks and management options discussed at the time of diagnosis of breast cancer.
dc.language.isoenen
dc.subjectBreast Canceren
dc.subject.meshAdult
dc.subject.meshAge Factors
dc.subject.meshBreast Neoplasms
dc.subject.meshChoice Behavior
dc.subject.meshFemale
dc.subject.meshGenes, BRCA1
dc.subject.meshGenes, BRCA2
dc.subject.meshGenetic Predisposition to Disease
dc.subject.meshGenetic Screening
dc.subject.meshHumans
dc.subject.meshMass Screening
dc.subject.meshMastectomy
dc.subject.meshMiddle Aged
dc.subject.meshRisk Factors
dc.titleSurgical decisions made by 158 women with hereditary breast cancer aged <50 years.en
dc.typeArticleen
dc.contributor.departmentAcademic Unit of Medical Genetics and Regional Genetics Service, St Mary's Hospital, Hathersage Road, Manchester, UK. gareth.evans@cmmc.nhs.uken
dc.identifier.journalEuropean Journal of Surgical Oncologyen
html.description.abstractAIM: To establish the uptake of contralateral risk reducing mastectomy in women informed of their risks and options at time of diagnosis of their primary unilateral breast cancer. METHODS: We have assessed the surgical choices of 70 women diagnosed with breast cancer <50 years as part of a family history surveillance program and fully informed about their contralateral risks and surgical options. We have compared this to women from other surgical clinics who were subsequently found to harbour a pathogenic BRCA1/2 mutation. RESULTS: Sixty-five percent (13/20) of BRCA1/2 mutation carriers and 59% (n=20/34) of those at the highest level of risk pre-diagnosis (33+% lifetime risk) opted for contra-lateral mastectomy in the study sample. In contrast only 10% (n=9/88) women identified as mutation carriers from other clinics opted for such surgery. CONCLUSIONS: We would suggest that women with a significant family history and therefore a high contra-lateral breast cancer risk, should have these risks and management options discussed at the time of diagnosis of breast cancer.


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