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dc.contributor.authorLiakopoulou, Effie F
dc.contributor.authorMutton, K J
dc.contributor.authorCarrington, D
dc.contributor.authorRobinson, Stephen P
dc.contributor.authorSteward, C G
dc.contributor.authorGoulden, N J
dc.contributor.authorCornish, J M
dc.contributor.authorMarks, David I
dc.date.accessioned2009-07-29T12:00:15Z
dc.date.available2009-07-29T12:00:15Z
dc.date.issued2005-10
dc.identifier.citationRotavirus as a significant cause of prolonged diarrhoeal illness and morbidity following allogeneic bone marrow transplantation. 2005, 36 (8):691-4 Bone Marrow Transplant.en
dc.identifier.issn0268-3369
dc.identifier.pmid16113671
dc.identifier.doi10.1038/sj.bmt.1705127
dc.identifier.urihttp://hdl.handle.net/10541/75823
dc.description.abstractInfective diarrhoea is common among allogeneic stem cell transplant (SCT) recipients, frequently caused by viruses and may be difficult to differentiate from acute graft-versus-host disease (GVHD). Viral pathogens may directly or indirectly impact upon transplant-related mortality. Rotavirus is one of the most common causes of diarrhoea worldwide, but one of the least studied causes of diarrhoea post SCT. In this retrospective study we describe 21 cases of confirmed rotavirus infection in allogeneic SCT recipients. Most of these cases may occur in clusters during the winter and spring period. Symptoms of rotaviral infection were diarrhoea (95%), vomiting (62%), abdominal pain (38%), weight loss and loss of appetite in 38 and 29% of the cases, respectively. Possible extraintestinal manifestations of rotavirus infection were observed. The duration of the symptoms in this series ranged from 4 days to 4 months with median of 15 days. Patients with rotavirus infection were invariably lymphopenic and/or on immunosuppression for GVHD. Of the patients diagnosed with rotavirus, 86% required hospitalisation. In 57% of the cases, other viral pathogens were isolated near to the rotavirus infection period. Rotavirus infection is an important cause of prolonged diarrhoea post SCT, causing significant morbidity and frequently requiring hospitalisation.
dc.language.isoenen
dc.subjectLeukaemiaen
dc.subject.meshAdolescent
dc.subject.meshAdult
dc.subject.meshBone Marrow Transplantation
dc.subject.meshChild
dc.subject.meshChild, Preschool
dc.subject.meshDiarrhea
dc.subject.meshHumans
dc.subject.meshInfant
dc.subject.meshLeukemia
dc.subject.meshLymphocyte Depletion
dc.subject.meshMorbidity
dc.subject.meshRotavirus
dc.subject.meshRotavirus Infections
dc.subject.meshT-Lymphocytes
dc.subject.meshTransplantation, Homologous
dc.titleRotavirus as a significant cause of prolonged diarrhoeal illness and morbidity following allogeneic bone marrow transplantation.en
dc.typeArticleen
dc.contributor.departmentBone Marrow Transplant Unit, Christie Hospital NHS Trust, Manchester, UK. Effie.Liakopoulou@christie-tr.nwest.nhs.uken
dc.identifier.journalBone Marrow Transplantationen
refterms.dateFOA2020-09-17T12:33:28Z
html.description.abstractInfective diarrhoea is common among allogeneic stem cell transplant (SCT) recipients, frequently caused by viruses and may be difficult to differentiate from acute graft-versus-host disease (GVHD). Viral pathogens may directly or indirectly impact upon transplant-related mortality. Rotavirus is one of the most common causes of diarrhoea worldwide, but one of the least studied causes of diarrhoea post SCT. In this retrospective study we describe 21 cases of confirmed rotavirus infection in allogeneic SCT recipients. Most of these cases may occur in clusters during the winter and spring period. Symptoms of rotaviral infection were diarrhoea (95%), vomiting (62%), abdominal pain (38%), weight loss and loss of appetite in 38 and 29% of the cases, respectively. Possible extraintestinal manifestations of rotavirus infection were observed. The duration of the symptoms in this series ranged from 4 days to 4 months with median of 15 days. Patients with rotavirus infection were invariably lymphopenic and/or on immunosuppression for GVHD. Of the patients diagnosed with rotavirus, 86% required hospitalisation. In 57% of the cases, other viral pathogens were isolated near to the rotavirus infection period. Rotavirus infection is an important cause of prolonged diarrhoea post SCT, causing significant morbidity and frequently requiring hospitalisation.


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