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dc.contributor.authorHadfield, John A
dc.contributor.authorGaukroger, Keira
dc.contributor.authorHirst, Nicholas
dc.contributor.authorWeston, Anna P
dc.contributor.authorLawrence, Nicholas J
dc.contributor.authorMcGown, Alan T
dc.date.accessioned2009-07-24T15:38:50Z
dc.date.available2009-07-24T15:38:50Z
dc.date.issued2005-06
dc.identifier.citationSynthesis and evaluation of double bond substituted combretastatins. 2005, 40 (6):529-41 Eur J Med Chemen
dc.identifier.issn0223-5234
dc.identifier.pmid15922837
dc.identifier.doi10.1016/j.ejmech.2004.12.008
dc.identifier.urihttp://hdl.handle.net/10541/75663
dc.description.abstractA series of combretastatins substituted with epoxides, amides and small alkyl groups has been synthesised and evaluated for cytotoxicity and their ability to inhibit the assembly of tubulin. The methyl and ethyl substituted phenols 36, 44 have shown potent antimitotic effects whilst exhibiting reduced cytotoxicity.
dc.language.isoenen
dc.subject.meshAmides
dc.subject.meshAntineoplastic Agents
dc.subject.meshBibenzyls
dc.subject.meshCell Cycle
dc.subject.meshCell Survival
dc.subject.meshEpoxy Compounds
dc.subject.meshFormazans
dc.subject.meshHumans
dc.subject.meshInhibitory Concentration 50
dc.subject.meshK562 Cells
dc.subject.meshMagnetic Resonance Spectroscopy
dc.subject.meshMolecular Structure
dc.subject.meshSpectrophotometry, Ultraviolet
dc.subject.meshStilbenes
dc.subject.meshTetrazolium Salts
dc.subject.meshTubulin
dc.subject.meshTubulin Modulators
dc.titleSynthesis and evaluation of double bond substituted combretastatins.en
dc.typeArticleen
dc.contributor.departmentCentre for Molecular Drug Design, Cockcroft Building, University of Salford, Manchester M5 4WT, UK. j.a.hadfield@salford.ac.uken
dc.identifier.journalEuropean Journal of Medicinal Chemistryen
html.description.abstractA series of combretastatins substituted with epoxides, amides and small alkyl groups has been synthesised and evaluated for cytotoxicity and their ability to inhibit the assembly of tubulin. The methyl and ethyl substituted phenols 36, 44 have shown potent antimitotic effects whilst exhibiting reduced cytotoxicity.


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