Synthesis and evaluation of double bond substituted combretastatins.
Authors
Hadfield, John AGaukroger, Keira
Hirst, Nicholas
Weston, Anna P
Lawrence, Nicholas J
McGown, Alan T
Affiliation
Centre for Molecular Drug Design, Cockcroft Building, University of Salford, Manchester M5 4WT, UK. j.a.hadfield@salford.ac.ukIssue Date
2005-06
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A series of combretastatins substituted with epoxides, amides and small alkyl groups has been synthesised and evaluated for cytotoxicity and their ability to inhibit the assembly of tubulin. The methyl and ethyl substituted phenols 36, 44 have shown potent antimitotic effects whilst exhibiting reduced cytotoxicity.Citation
Synthesis and evaluation of double bond substituted combretastatins. 2005, 40 (6):529-41 Eur J Med ChemJournal
European Journal of Medicinal ChemistryDOI
10.1016/j.ejmech.2004.12.008PubMed ID
15922837Type
ArticleLanguage
enISSN
0223-5234ae974a485f413a2113503eed53cd6c53
10.1016/j.ejmech.2004.12.008
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