Synthesis and evaluation of double bond substituted combretastatins.
AuthorsHadfield, John A
Weston, Anna P
Lawrence, Nicholas J
McGown, Alan T
AffiliationCentre for Molecular Drug Design, Cockcroft Building, University of Salford, Manchester M5 4WT, UK. email@example.com
MetadataShow full item record
AbstractA series of combretastatins substituted with epoxides, amides and small alkyl groups has been synthesised and evaluated for cytotoxicity and their ability to inhibit the assembly of tubulin. The methyl and ethyl substituted phenols 36, 44 have shown potent antimitotic effects whilst exhibiting reduced cytotoxicity.
CitationSynthesis and evaluation of double bond substituted combretastatins. 2005, 40 (6):529-41 Eur J Med Chem
JournalEuropean Journal of Medicinal Chemistry
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