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    Immune control of human papillomavirus (HPV) associated anogenital disease and potential for vaccination.

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    Authors
    Stern, Peter L
    Affiliation
    CR UK Immunology Group, Department of Immunology, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester M20 4BX, UK. pstern@picr.man.ac.uk
    Issue Date
    2005-03
    
    Metadata
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    Abstract
    This review discusses: (1) immune mechanisms relevant to the natural control of a human papillomavirus (HPV) infection; (2) viral strategies to evade or subvert immune attack; (3) the significance of immune escape as a feature of the evolution of invasive cancer; (4) vaccine strategies for prevention and/or therapy. HPV infection and associated malignancy can induce humoral and cellular immunity to capsid and oncogene viral proteins, but it is not always clear whether such responses are a consequence of the disease rather than the resolving factor(s). Prophylactic strategies are utilising virus-like particles (VLP) composed of the L1 viral capsid protein to induce neutralising antibodies, while therapeutic approaches are aimed at generating specific T cells targeted at the viral E6 and/or E7 oncogenes. Thus far, HPV VLP vaccines have proved clinically efficacious in the early clinical trials to prevent infection. Different types of therapeutic vaccines including peptide, protein, DNA or viral vector encoded have proved safe and immunogenic in patients, although there is often no correlation with clinical outcome. Understanding the equilibrium between viral and immunological factors will be important in providing the appropriate tools to evoke effective prophylactic and therapeutic immunity. It seems likely that combined prophylactic and therapeutic vaccine approaches could offer the best prospect for any significant reduction in death from cervical cancer worldwide.
    Citation
    Immune control of human papillomavirus (HPV) associated anogenital disease and potential for vaccination. 2005, 32 Suppl 1:S72-81 J. Clin. Virol.
    Journal
    Journal of Clinical Virology
    URI
    http://hdl.handle.net/10541/75655
    DOI
    10.1016/j.jcv.2004.12.005
    PubMed ID
    15753015
    Type
    Article
    Language
    en
    ISSN
    1386-6532
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.jcv.2004.12.005
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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